Regenerative Medicine in the Genitourinary System / Farshid Sefat and Morvarid Saeinasab, editors.

Format:

Book

Contributor:

Sefat, Farshid, editor.

Saeinasab, Morvarid, editor.

Language:

English

Subjects (All):

Extracellular matrix.

Tissue engineering.

Physical Description:

1 online resource (352 pages)

Edition:

First edition.

Place of Publication:

London, England : Academic Press, [2024]

Summary:

Regenerative Medicine in the Genitourinary System gives the reader a comprehensive overview of tissue engineering used to treat genitourinary disorders and infertility, also providing a great learning platform for researchers in different fields such as cell biology, pharmaceutics, clinicians, chemists, material scientists, and more.

Contents:

Front Cover

Regenerative Medicine in the Genitourinary System

Copyright

Contents

Contributors

1 - Introduction

1 - Genitourinary tissue engineering: Promises, advances, and challenges

1.1 Introduction

1.2 Regenerative medicine

1.3 Principles of tissue engineering

1.3.1 Source of cells

1.3.1.1 Stem cells

1.3.2 Biomaterials

1.3.2.1 Extracellular matrix

1.3.2.2 Scaffolds

1.3.3 Fabrication

1.3.4 Structure and material properties

1.3.5 Requirements of scaffold design

1.3.6 Growth factors

1.3.7 Decellularization

1.4 Genitourinary system anatomy and physiology

1.4.1 Urinary structure and function

1.4.2 Genital structure and function

1.4.2.1 Female genitalia

1.4.2.2 Male genitalia

1.5 Genitourinary conditions

1.5.1 Affecting the ureter

1.5.2 Diseases that lead to damage or loss of function of the kidneys

1.5.3 Conditions that specifically affect females

1.5.4 Conditions that specifically affect males

1.6 Current treatments and potential drawbacks

1.7 Genitourinary tissue engineering

1.7.1 Urethra

1.7.2 Bladder

1.7.3 Genital tissues

1.7.4 Kidney

1.8 Summary

References

Further reading

2 - Urinary system

2 - The progress in tissue engineering of kidney

2.1 Introduction

2.2 Anatomy and physiology

2.3 History of kidney transplants and treatments

2.3.1 Biomaterials and scaffolds

2.3.1.1 Natural biomaterials

2.3.1.1.1 Collagen

2.3.1.1.2 Gelatine

2.3.1.1.3 Fibrin

2.3.1.1.4 Chitosan

2.3.1.1.5 Alginate

2.3.1.1.6 Agarose

2.3.1.1.7 Hyaluronic acid

2.3.1.2 Synthetic biomaterials.

2.3.1.2.1 Polylactic acid

2.3.1.2.1 Polylactic acid

2.3.1.2.2 Poly lactic-co-glycolic acid

2.3.1.2.3 Polyglycolic acid

2.3.1.2.4 Polycaprolactone

2.3.2 Fabrication techniques

2.3.2.1 Electrospinning

2.3.2.2 Decellularization

2.3.2.3 3D printing

2.3.2.4 Other fabrication techniques

2.3.3 Cell culture

2.3.3.1 Primary renal cells

2.3.3.2 Stem cells

2.3.3.2.1 Embryonic stem cells

2.3.3.2.2 Fetal stem cells

2.3.3.2.3 Adult stem cells

2.3.3.3 Progenitor cells

2.3.4 Growth factor

2.3.4.1 Hepatocyte growth factor

2.3.4.2 Insulin-like growth factor 1

2.3.4.3 Fibroblast growth factor

2.4 Tissue engineering of a kidney

2.5 Discussion and conclusion

3 - The progress in tissue engineering of bladder

3.1 Introduction

3.1.1 Bladder physiology and structure

3.1.1.1 Muscle structure

3.1.1.2 Nervous structure

3.1.2 Bladder function

3.2 Bladder disease

3.2.1 Urinary incontinence

3.2.2 Interstitial cystitis

3.2.3 Bladder cancer

3.3 Biomaterials for bladder regenerative medicine

3.3.1 Scaffold

3.3.1.1 Polymer scaffold

3.3.1.2 Acellular matrix scaffold

3.3.1.3 Composite polymer scaffolds

3.3.2 Cells

3.4 Tissue engineering for bladder

3.4.1 Engineering for stress incontinence

3.4.2 Tissue-engineered cystoplasty treatment for neurogenic bladder

3.4.3 Urinary bladder bioprinting

3.5 Conclusion

4 - The progress in tissue engineering of urethra

4.1 Introduction

4.2 Etiology and anatomy

4.3 Tissue engineering of urethra

4.3.1 Cell sources

4.3.1.1 Progenitor cells

4.3.1.2 Stem cells.

4.3.2 Biomaterial scaffolds for urethral regeneration

4.3.2.1 Decellularized matrixes

4.3.2.2 Natural material for scaffolding

4.3.2.3 Synthetic material for scaffolding

4.3.3 Growth factors

4.4 Clinical issues and discussion

5 - The progress in ureter tissue engineering

5.1 Introduction

5.2 Ureters anatomy

5.2.1 General anatomy

5.2.2 Microscopic anatomy

5.3 Physiology

5.4 Diseases of ureter

5.4.1 Congenital anomalies

5.4.1.1 Double and bifid ureters

5.4.1.2 Ureteropelvic junction obstruction

5.4.2 Tumors and tumor-like lesions

5.4.3 Ureter stones

5.5 Ureter tissue engineering

5.5.1 Repair of a ureteral dysfunction

5.5.2 Different biomaterials used

5.5.3 Sources of regenerative cells

5.5.4 Preimplantation seeding

5.5.5 Decellularized tissue and synthetic polymers in scaffolding

5.5.6 Repair of full-circumference ureteral defects

5.5.7 Models using animals

5.6 Discussion and challenges

3 - Male reproductive system

6 - The progress in tissue engineering of penile corporal tissue

6.1 Introduction

6.2 Disease/disorders related to penile corporal tissue

6.2.1 Balanitis

6.2.2 Epispadias

6.2.3 Hypospadias

6.2.4 Penile cancer

6.2.5 Peyronie's disease

6.2.6 Phimosis and paraphimosis

6.2.7 Priapism

6.3 Materials used for transplantation for penile corporal tissue

6.4 Physical bodies

6.5 Albuginea tunica

6.6 Latest and previous tissue engineering approaches for penile corporal tissue

6.7 Cell/stem cell used in penile corporal tissue

6.8 Conclusion

7 - The progress in tissue engineering of prostate

7.1 Introduction

7.2 Anatomy and histology of the prostate

7.3 Conditions of the prostate

7.3.1 Prostate cancer

7.3.1.1 Stages of PCa and treatments at each stage.

7.3.1.2 Treatment of PCa

7.3.2 Prostatitis

7.3.2.1 Types of prostatitis

7.4 Need for prostate tissue engineering

7.5 Tissue engineering approach

7.5.1 Injection stem cell therapy

7.5.2 Tissue generation

7.5.3 Biomaterials

7.5.3.1 Porous chitosan alginate

7.5.3.2 Collagen

7.6 Conclusion

8 - The progress in tissue engineering of testicle

8.1 Introduction

8.2 Anatomy and physiology of the testes

8.3 Pathophysiology of the testicles

8.3.1 Cryptorchidism

8.3.2 Testicular microlithiasis

8.3.3 Hydrocele

8.3.4 Epididymitis

8.3.5 Varicocele

8.3.6 Spermatocele

8.3.7 Testicular torsion

8.3.8 Hypogonadism

8.3.9 Testicular cancer

8.4 Biomaterials used for testicular tissue engineering

8.4.1 Extracellular testicular matrix

8.4.2 Decellularized testicular matrix

8.4.3 Natural biomaterials

8.4.3.1 Collagen

8.4.3.2 Alginate

8.4.3.3 Silk

8.4.3.4 Fibrin

8.4.3.5 Hyaluronic acid

8.4.3.6 Chitosan

8.4.4 Synthetic biomaterials for a testicular implant

8.5 History of biomaterials used for testicular prostheses

8.6 Tissue engineering approach

8.6.1 Cell-based tissue engineering

8.6.2 Scaffold-based tissue engineering

8.6.2.1 Scaffolding techniques used for testis cell culture

8.6.2.1.1 3D printing of testes scaffolds

8.6.2.1.2 Manufacturing of 3D testicular prostheses

8.6.2.1.3 Electrospinning technique

8.6.2.1.4 Extracellular matrix scaffolding technique

8.6.2.1.5 Decellularization

8.6.3 Stem cell used in tissue engineering approaches for testes

8.6.3.1 The embryonic stem cells.

8.6.3.2 Adult stem cells

8.6.3.3 The induced pluripotent stem cells (iPS)

8.6.3.4 Testicular stem cells

8.6.3.5 Spermatogonia stem cells (SSC)

8.6.4 Fibroblast growth factors

8.7 Conclusion

9 - Tissue engineering applications for erectile dysfunction

9.1 Introduction

9.2 Anatomy and physiology of penis

9.2.1 Anatomy of corpus cavernosum

9.2.2 Mechanism of erection

9.3 Risk factors and diseases associated with ED

9.4 Current treatments

9.4.1 Phosphodiesterase type-5 inhibitors (PDE5i)

9.4.2 Intracavernosal injection

9.4.3 Testosterone therapy

9.4.4 Intraurethral drugs

9.4.5 Penile implants

9.4.6 Shockwave therapy

9.4.7 Penile revascularization

9.5 Biomaterials used for CC scaffolds

9.6 Desired properties of scaffolds

9.7 Cells used

9.8 Tissue engineering approach used

9.9 Engineered prosthesis

9.10 Engineered corpus cavernosum

9.11 Challenges

9.12 Conclusions

10 - Tissue engineering strategies to treat male infertility

10.1 Introduction

10.2 Male reproductive system physiology

10.2.1 Testicles

10.2.2 Pennis

10.2.3 Urethra

10.2.4 Prostate

10.2.5 Vas deferens

10.3 Male infertility

10.3.1 Causes of male infertility

10.3.2 Evaluation of the infertile male

10.4 Current treatments

10.4.1 Surgical treatment for male infertility

10.4.2 Hormonal treatment

10.4.3 Gamete (sperm) donation

10.5 Tissue engineering approaches for treating male infertility

10.5.1 Stem cells

10.5.2 Scaffolds

10.5.3 Decellularized extracellular matrix

10.5.4 3D bioprinting

10.6 Conclusion

4 - Female reproductive system

11 - The progress in tissue engineering of uterus

11.1 Introduction

11.2 Uterus anatomy and physiology

11.3 Uterus physiology

11.4 Common uterine diseases and disorders.

11.4.1 Genetic disorders.

Notes:

Includes bibliographical references and index.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

ISBN:

9780443158353

0443158355

OCLC:

1431016072