Sinusoidal Cells in Liver Diseases : Role in Their Pathophysiology, Diagnosis, and Treatment / Jordi Gracia-Sancho, editors.

Format:

Book

Contributor:

Gracia-Sancho, Jordi, editor.

Language:

English

Subjects (All):

Liver--Diseases--Congresses.

Liver.

Liver cells--Congresses.

Liver cells.

Physical Description:

1 online resource (564 pages)

Edition:

First edition.

Place of Publication:

San Diego, CA : Academic Press, [2024]

Summary:

Sinusoidal Cells in Liver Diseases: Role in their Pathophysiology, Diagnosis, and Treatment provides a state-of-the-art review on recent advances surrounding the role of liver sinusoidal cells (LSECs, HSCs, macrophages, and other non-parenchymal cells) in acute and chronic liver diseases.

Contents:

Front Cover

Sinusoidal Cells in Liver Diseases

Copyright

Dedication

Contents

Contributors

About the editor

Preface

I - The liver sinusoid - General concepts

1 - The unique architecture of the hepatic sinusoid

1. Liver sinusoidal endothelial cells

1.1 Morphology and function of liver sinusoidal endothelial cells

1.1.1 Filtering effect

1.1.2 Scavenger and immunological functions

1.2 Characteristics and regulatory mechanism of fenestra

1.3 Origin of liver sinusoidal endothelial cells and their involvement in organogenesis

1.4 Artificial livers and liver sinusoidal endothelial cells differentiation from iPS cells

2. Kupffer cells

2.1 Morphology and function of Kupffer cells in normal liver

2.2 Origin of Kupffer cells

2.3 Phenotype and heterogeneity of Kupffer cells

2.4 Kupffer cells differentiation from iPS cells

3. Hepatic stellate cells

3.1 Morphology and function of hepatic stellate cells

3.1.1 Morphology

3.1.2 Vitamin A storage

3.1.3 Cell contraction

3.2 Development of hepatic stellate cells

3.3 Heterogeneity of hepatic stellate cells

3.4 Property changes in hepatic stellate cells due to cellular senescence

3.5 Hepatic stellate cell differentiation from iPS cells

4. Extracellular matrix and sinusoidal structures

4.1 Extracellular matrix in the liver

4.2 Contribution of extracellular matrix to hepatic functions

Supplementary material

References

2 - Sinusoidal cell interactions-From soluble factors to exosomes

1. Introduction

2. Communication of sinusoidal cells during homeostasis

2.1 Sinusoidal cell communication during homeostasis via soluble factors

2.2 Sinusoidal cells communication during homeostasis via extracellular vesicles

3. Role of soluble factors in liver disease.

3.1 Parenchymal to nonparenchymal interactions via SFs

3.1.1 Hepatocyte-LSEC cross-talk

3.1.2 Hepatocyte-immune cells cross-talk

3.1.3 Hepatocyte-HSCs cross-talk

3.2 Nonparenchymal to nonparenchymal interactions via SFs

3.2.1 LSEC-HSC cross-talk

3.2.2 LSEC-immune cells cross-talk

3.2.3 HSC-immune cells cross-talk

3.2.4 Immune cell cross-talk

4. Cross-talk between different sinusoidal cells via exosomes in the spectrum of liver disease

4.1 Hepatocyte-derived EVs and cross-talk between different sinusoidal cells

4.1.1 Hepatocyte-derived EVs and their effects on hepatocytes

4.1.2 Hepatocyte-derived EVs and their effects on immune cells

4.1.3 Hepatocyte-derived EVs and their effects on HSCs

4.1.4 Hepatocyte-derived EVs and their effects on LSEC

4.1.5 Hepatocyte-derived EVs and their effects on cholangiocytes

4.2 LSEC-derived EVs and cross-talk between different sinusoidal cells

4.2.1 LSEC-derived EVs and their effects on hepatocytes

4.2.2 LSEC-derived EVs and their effects on HSCs

4.3 HSC-derived EVs and cross-talk between different sinusoidal cells

4.3.1 HSC-derived EVs and their effects on quiescent and aHSCs

4.3.2 HSC-derived EVs and their effects on hepatocytes

4.3.3 HSC-derived EVs and their effects on LSECs

4.3.4 HSC-derived EVs and their effects on immune cells

4.4 Immune cell-derived EVs and cross-talk between different sinusoidal cells

4.4.1 Immune cell-derived EVs and their effects on immune cells

4.4.2 Immune cell-derived EVs and their effects on hepatocytes

4.4.3 Immune cell-derived EVs and their effects on HSCs

5. Conclusions and future perspectives

Abbreviations

Acknowledgments and funding

3 - Sinusoidal cells and liver immunology

1. Liver as an immune organ

1.1 Microarchitecture of the liver

1.1.1 Liver zonation.

1.2 Liver immune system

1.2.1 Innate immunity

1.2.2 Adaptive immunity

2. Sinusoidal cells involved in liver immunity

2.1 Liver sinusoidal endothelial cells

2.2 Kupffer cells and other liver-resident macrophages

2.3 Hepatic stellate cells

2.4 Dendritic cells

2.5 Resident lymphocytes

2.5.1 Innate lymphoid cells

2.5.2 Innate-like T lymphocytes

2.5.3 B cells

2.6 Other liver cells contributing to liver immunity

2.6.1 Hepatocytes

2.6.2 Platelets

2.6.3 Neutrophils

3. Conclusion

Acknowledgement

4 - Liver sinusoidal cells in aging

1.1 Importance of studying aging in the liver

1.2 Overview of the hepatic sinusoid and its components

2. The hepatic sinusoid in young, healthy individuals

2.1 Sinusoidal cells in young healthy individuals

2.2 Hepatic microcirculation regulation in young healthy individuals

3. Impact of aging on the hepatic sinusoid

3.1 Effects of aging on the structure and function of LSECs, Kupffer cells, and HSCs

3.2 Changes in the hepatic microcirculation with aging

4. Molecular mechanisms underlying age-related changes in the hepatic sinusoid

4.1 Extracellular matrix alterations

4.2 Deregulation of growth factors and cytokines

4.3 Inflammation and oxidative stress

5. Clinical implications of age-related changes in the hepatic sinusoid

5.1 Challenges in diagnosis and treatment of liver disease in older adults

5.2 Potential therapeutic approaches for age-related liver dysfunction

5.2.1 Pharmacological interventions

5.2.2 Lifestyle interventions

6. Future directions for research on aging and the hepatic sinusoid

6.1 New technologies and experimental approaches to study the aged liver

7. Conclusions

5 - Microscopic imaging of hepatic sinusoidal cells: Fifty years in the making.

1. Introduction

2. The liver and its primary cells-Hepatic parenchymal cells

3. Liver sinusoidal cells

3.1 Liver sinusoidal endothelial cells

3.2 Kupffer cells (Liver-resident macrophages)

3.3 Hepatic stellate cells

3.4 Liver-associated natural killer cells (Pit cells)

4. Emerging microscopy approaches

4.1 Multidimensional light and laser microscopy (Lattice light sheet and superresolution light microscopy)

4.2 High-volume and cryogenic electron microscopy

4.3 Multimodal and correlative microscopy

4.4 Atomic force microscopy

4.5 Data on the fly, and deep learning analysis

5. Conclusion and outlook

Acknowledgments

6 - The liver sinusoid at single-cell level

2. Single-cell technologies and analytics

2.1 Defining cellular heterogeneity

2.2 Differential abundance and differential expression analysis

2.3 Trajectory inference and cellular differentiation

2.4 Gene regulation and transcription factor enrichment

2.5 Ligand-receptor interaction analyses

2.6 Single-cell multiomics

2.7 Single-nucleus RNA-seq

3. The homeostatic liver sinusoid at single-cell resolution

3.1 Liver epithelia

3.2 Endothelial cells

3.3 Mesenchymal cells

3.4 Immune cells

3.4.1 Myeloid cells

3.4.2 T and NK cells

3.4.3 B cells

4. Single-cell analysis of the sinusoid during acute liver injury and regeneration

4.1 Hepatocyte regenerative responses

4.2 Biliary regeneration and the ductular reaction

4.3 Hepatic stellate cells

4.4 Liver sinusoidal endothelial cells

4.5 Myeloid cells

5. Sinusoidal responses to chronic liver injury and fibrosis at single-cell resolution

5.1 The role of macrophages

5.2 Hepatic stellate cell heterogeneity

5.3 Vascular remodeling in chronic liver injury

5.4 Hepatocytes in CLD

5.5 Other immune cells.

5.5.1 T cells

5.5.2 B cells

5.5.3 Dendritic cells

6. Single-cell analysis of sinusoidal cells in liver cancer

6.1 Hepatocellular carcinoma

6.1.1 Hepatocytes

6.1.2 Hepatic stellate cells

6.1.3 Macrophages

6.1.4 Neutrophils

6.1.5 B cells and plasma cells

6.1.6 HCC relapse

6.2 Intrahepatic cholangiocarcinoma

7. Future directions

7.1 Spatial profiling

7.2 Assessment of response to therapies at single-cell resolution

7.3 Tissue access

8. Conclusions

7 - Advanced models to study liver sinusoids

2. 3D bioengineered models

3D bioprinting

4. Liver-on-a-chip

5. Spheroids and organoids

5.1 Vascularized spheroids/organoids developed with primary cells

5.2 Generation of vascularized liver buds from iPSCs

5.3 iPSCs-derived liver vascular endothelial cells

6. Precision-cut liver slices

7. Animal models

8. Conclusion

8 - Strategies to target and genetically modify the liver sinusoid

1. The liver sinusoidal endothelial cell

1.1 Scavenging

1.2 LSEC-secreted proteins

1.2.1 Factor VIII

1.2.2 von Willebrand factor

2. Genetic disorders of the LSEC

2.1 Hemophilia A

2.2 von Willebrand disease

2.3 α1 antitrypsin deficiency

2.4 Other related disorders

3. Gene therapy

3.1 CRISPR/Cas9

3.2 siRNA

4. Delivery approaches

4.1 Viral vectors

4.2 Physical methods

4.2.1 Microinjection

4.2.2 Electroporation

4.2.3 Hydrodynamic delivery

4.3 Nanotechnology

5. Targeting the LSEC

5.1 Viral vector delivery

5.2 Nanotechnology delivery

6. Conclusion

II - The liver sinusoid in acute liver injury

9 - Drug-induced liver injury

1. The hepatic sinusoid

2. Liver sinusoidal endothelial cells.

2.1 Embriology of the liver sinusoidal endothelial cells.

Notes:

Includes bibliographical references and index.

Description based on publisher supplied metadata and other sources.

Description based on print version record.

ISBN:

9780323952637

0323952631

OCLC:

1429612302