Activation and Detoxification Enzymes : Functions and Implications / by Chang-Hwei Chen.

Format:

Book

Author/Creator:

Chen, Chang-Hwei, author.

Language:

English

Subjects (All):

Human physiology.

Enzymology.

Pharmacology.

Nutrition.

Bioinformatics.

Human Physiology.

Computational and Systems.

Local Subjects:

Human Physiology.

Enzymology.

Pharmacology.

Nutrition.

Computational and Systems.

Physical Description:

1 online resource (257 pages)

Edition:

2nd ed. 2024.

Place of Publication:

Cham : Springer Nature Switzerland : Imprint: Springer, 2024.

Summary:

This book discusses the many advances in the understanding of the functions and implications of activation and detoxification enzymes. This organized, concise overview will meet the needs of those who are initially exposed to this important subject, particularly for students and researchers in the areas of biomedical sciences, biochemistry, nutrition, pharmacology, and chemistry. The book will also be valuable to advanced researchers. The book discusses subjects associated with foreign-compound-metabolizing enzymes with emphasis on biochemical aspects, including lipophilic foreign compounds, activation and detoxification enzymes, metabolic enzyme catalytic properties, reactive metabolic intermediates, biomedical and biochemical effects, genetic polymorphisms, enzyme inducibility, enzyme modulation for health benefits, dietary-related enzyme modulators, and structural characteristics of enzyme inducers. This new edition is updated throughout and features completely new chapters on Oxidative and Electrophilic Stresses, Metabolite- Mediated Disease Conditions, and Defense Mechanism: Nrf2-ARE Pathway. .

Contents:

Overview

Foreign Compounds: Foods, Drugs, Chemicals and Life Styles

Transport and Excretion of Foreign Compounds

Metabolic Conversion of Foreign Compounds

Phase I Activation Enzymes

Phase II Detoxification Enzymes

Catalytic Reactions of Activation Enzymes

Catalytic Reactions of Detoxification Enzymes

Reactive Intermediates and their Interactions

Metabolite - Associated Cell Toxicities

Oxidative Stress and Electrophilic Stress

Metabolic Enzymes: Polymorphism and Species Differences

Defense Against Oxidative Stress: Nrf2-ARE Pathway

Inducibility of Metabolic Enzymes

Inducers of Metabolic Enzymes

Diversified Classes of Enzyme Modulators

Metabolite - Mediated Disease Conditions

Metabolic Enzyme Induction for Health Benefits

Diet Effects on Metabolic Enzymes.

Notes:

Includes bibliographical references and index.

ISBN:

3-031-55287-3