Gasotransmitters in Organ Transplantation : A New Era in Transplant Medicine / by George J. Dugbartey.

Format:

Book

Author/Creator:

Dugbartey, George J.

Language:

English

Subjects (All):

Nephrology.

Surgery.

General Surgery.

Local Subjects:

Nephrology.

General Surgery.

Physical Description:

1 online resource (307 pages)

Edition:

1st ed. 2024.

Place of Publication:

Cham : Springer Nature Switzerland : Imprint: Springer, 2024.

Summary:

This book covers recent pre-clinical and clinical developments in gasotransmitters (nitric oxide, carbon monoxide and hydrogen sulfide) in all transplantable solid organs – kidney, heart, lung, liver, pancreas and intestine. Gasotransmitters are a class of small endogenously produced gaseous signaling molecules that play important roles in cellular homeostasis and impact physiological and pathophysiological processes. Recently, these homeostatic gases have emerged as potent cytoprotective mediators, possessing therapeutic properties that enable them exhibit their intracellular signaling functions. Hence, alterations in their physiological levels have been associated with various pathologies including warm and cold ischemia-reperfusion injury (IRI) in organ transplantation. In the context of organ transplantation, a novel therapeutic strategy that is being investigated involves administration of these gasotransmitters to the organ donor or recipient before or after transplantation, or supplementation of standard preservation solution with gasotransmitters during organ graft preservation to mitigate transplant-induced IRI. This book is divided into three parts for easy access: Hydrogen Sulfide in Organ Transplantation, Carbon Monoxide in Organ Transplantation, and Nitric Oxide in Organ Transplantation. By presenting recent advances in organ graft protection mediated by gasotransmitters against warm and cold IRI and its associated post-transplant complications in pre-clinical models of organ transplantation and some selected clinical cases, this book aims to be a surgical guide specifically for organ transplant surgeons who seek to improve routine transplant procedure involving donor organ procurement, preservation, engraftment and patient (graft) evaluation during early post-transplant period. In addition, the book also seeks to lay the foundation for future clinical applications of gasotransmitters, while serving as an excellent resource for both educational didactic purposes in transplant surgery and research.

Contents:

PART I: Hydrogen Sulfide in OrganTransplantation

Chapter 1: Gasotransmitters

Chapter 2: Pharmacological Modification of Organ Preservation Solution with Hydrogen Sulfide for Improved Kidney Transplantation Outcome

Chapter 3: Hydrogen Sulfide Donor Molecules against Cold Ischemia-Reperfusion Injury in Preclinical Models of Solid Organ Transplantation

Chapter 4: Pre-Treatment of Transplant Donors with Hydrogen Sulfide to Protect against Warm and Cold Ischemia-Reperfusion Injury in Kidney and Other Transplantable Solid Organ Grafts

PART II: Carbon Monoxide in Organ Transplantation

Chapter 5: Application of Carbon Monoxide in Kidney and Heart Transplantation: A Novel Pharmacological Strategy for a Broader Use of Suboptimal Renal and Cardiac Grafts

Chapter 6: Carbon Monoxide as an Emerging Pharmacological Tool to Improve Lung and Liver Transplantation Protocols

Chapter 7: Emerging Role of Carbon Monoxide in Intestinal Transplantation

Chapter 8: Carbon Monoxide in Pancreatic Islet Transplantation: A New Therapeutic Alternative to Patients with Severe Type 1 Diabetes Mellitus

PART III: Nitric Oxide in Organ Transplantation

Chapter 9: Protective Role of Nitric Oxide in Kidney and Heart Transplantation

Chapter 10: Beneficial Effects of Nitric Oxide in Lung and Liver Transplantation

Chapter 11: Therapeutic Potential of Nitric Oxide in Pancreas and Intestinal Transplantation.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

9783031480676

3031480678

OCLC:

1428782803