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Gallstone Formation, Diagnosis, Treatment and Prevention.
- Format:
- Book
- Author/Creator:
- Shaktiswarupa Chaitanya.
- Language:
- English
- Subjects (All):
- Gallstones.
- Gallbladder.
- Physical Description:
- 1 online resource (299 pages)
- Edition:
- 1st ed.
- Place of Publication:
- San Diego : Elsevier Science & Technology, 2024.
- Summary:
- This book provides a comprehensive analysis of gallstone formation, diagnosis, treatment, and prevention. Edited by Rajani Sharma, Shubha Rani Sharma, and Ram Prasad, it gathers contributions from various experts in the field, focusing on topics such as the historical perspective of gallstones, comparative studies with urinary and kidney stones, and the role of the gallbladder in metabolism and immunity. It explores factors affecting gallstone formation, including molecular mechanisms, genetic factors, and the influence of microflora. The book also discusses the implications of gallstones in diseases like acute pancreatitis and gallbladder cancer, as well as diagnostic tools and treatments, including chemical, herbal, and probiotic approaches. Intended for medical professionals, researchers, and students, it aims to provide updated research and practical insights into gallstone management. Generated by AI.
- Contents:
- Front Cover
- Gallstone Formation, Diagnosis, Treatment, and Prevention
- Copyright Page
- Contents
- List of contributors
- Preface
- Introduction
- 1 Historical perspective of gallstones
- History of gallstone classification
- Classification system for gallstone
- Former classification of gallstones
- Recent classifications of gallstones
- Conclusion
- References
- 2 Comparative study of gallstone with urinary stone and kidney stone
- Urinary stones
- Gallstones
- Types of gallstones
- Cholesterol gallstones
- Pigment stones
- Mixed stones
- Pathophysiology of gallstones
- Kidney stones
- Calcium containing stones
- Uric acid stones
- Struvite stones
- Cystine stones
- Protease-related stones
- Comparative analysis of gallstone with kidney stones
- Gender prevalence
- Age prevalence
- Prevalence based on types of stones
- Chemical composition
- Conclusions
- 3 Role of the gallbladder in our metabolism and immune system
- Bile acid production, secretion and storage
- Bile acid action in immunity and metabolism
- Physiology of gallbladder
- Epithelial cells
- Lamina propria
- Muscle layer
- Formation, storage, and secretion of bile
- Formation of bile acid
- Classical or formal pathway
- Alternate or acidic pathway
- Enterohepatic circulation of bile acids
- Bile acid and blood-brain barrier (BBB)
- Role of gallbladder and biliary tree in immunity
- Role of gallbladder in our metabolism
- Conflict of interest
- 4 Factors prevailing for gallstone formation
- Who is at the risk of gallstones?
- Factors underlying gallstone formation
- Hepatobiliary disease
- Diet
- Intestinal hypomotility and gallbladder motility
- Metabolic syndrome, diabetes, and insulin resistance
- Genetic trait.
- Ion and water absorption
- Acknowledgment
- 5 Role of liver in gallstone formation
- Epidemiology
- Pathogenesis of gallstones
- Supersaturation of bile
- Role of mucus
- Calcium in bile
- Phospholipids in bile
- Pigment gallstones
- Black pigment gallstones
- Brown pigment gallstones
- Mixed gallstones
- Classification by clinical aspects
- Asymptomatic gallstones
- Symptomatic gallstones
- Factors affecting gallstone formation
- Genetic factors for gallstone formation
- Gallbladder contraction
- Microbiome
- Role of estrogen in gallstone formation
- Obesity
- Carbohydrate metabolism
- Treatment
- Observation for asymptomatic gallstones
- Prophylactic cholecystectomy
- Spectroscopic approaches to analyze and detect gallstones
- Fourier transform infrared
- Wavelength dispersive X-ray fluorescence spectroscopy
- Time-of-flight secondary ion mass spectrometry
- Laser-induced breakdown spectroscopy
- Conflicts of interest
- 6 Molecular aspect of gallstone formation: a systematic review
- Prevalence and incidence
- Pathophysiology of gallstone formation
- Molecular mechanisms involved in cholesterol gallstone formation
- Role of trace elements in gallstone formation
- Genetic mechanism of gallstone formation
- Cholecystokinin A receptor gene polymorphism and cholelithiasis
- Clinical presentation and diagnosis
- 7 Relation of the microflora of oral cavity and gallbladder
- Oral microbiome
- Oral microbiome: a complex ecological community
- Association between oral microbiome and overall health
- Bacterial communities in the oral microbiome.
- Helicobacter pylori and Helicobacter spp. and gallstones
- Gallstone microbiome
- 8 Gut microbial physiology and gallstone formation
- Relation among gallstone disease and microbiota
- Pathogenesis of gallstone formation
- Metabolic process of gallstone formation
- Gallstone detection
- Future prospects
- 9 Gallstone: a factor for acute pancreatitis
- Etiology
- Common channel hypothesis
- Duodenal reflux hypothesis
- Ductal hypertension hypothesis
- Pathophysiology
- Gallstone formation
- Cholesterol gallstone
- Pigment gallstone
- Cellular level changes
- Excess calcium
- Premature trypsinogen activation
- Autophagy failure
- Immune response
- Disease models
- Overview of models in acute pancreatitis
- Duct ligation model
- Closed duodenal loop acute pancreatitis model
- Diagnosis
- Physical examination
- Biochemical markers
- Imaging techniques
- Ultrasonography
- Computed tomography
- Magnetic resonance cholangiography
- Management of the disease
- Indices of intensity
- Nutritional support
- Initial management
- Antibiotic treatment
- Surgical intervention
- Further reading
- 10 Gallstone: a lead factor for gallstone cancer
- Risk factors
- Signs and symptoms
- Pathogenesis
- Staging
- Diagnostic imaging
- Management
- 11 Diagnostic tools for gallstone
- Reasons to develop gallstone
- Common symptoms of gallstone
- Gallbladder conditions
- Gallstones (cholelithiasis)
- Cholecystitis
- Gallbladder cancer
- Gallstone pancreatitis
- Risk factors of having gallstones
- How are gallstones diagnosed and evaluated?
- Blood test
- Plain films
- Ultrasound scan.
- MRI scan
- Cholangiography
- CT scan
- Nuclear medicine
- 12 Role of probiotics in gallstone treatment
- Biliary microbiota
- Probiotics
- 13 Chemical and herbal treatment for gallstone treatment
- Cholesterol stones
- Brown pigment stones
- Black pigment stones
- Choleretic and cholagogic effects of anti-cholelithiac plants
- Herbal alternatives for the treatment of gallstones
- Kalanchoe pinnatum
- Chemical constituents
- Therapeutic effects
- Achillea millefolium L
- Agrimonia eupatoria L
- Aloe vera (L.) Burm. f
- Apium graveolens L
- Plants exhibiting choleretic attributes
- Plants exhibiting cholegogic attributes
- Chemical alternatives for the treatment of gallstones
- Ursodiol
- Mechanism of action
- Chenodiol
- 14 The implication of gall stones in gallbladder cancer and recent updates on its epidemiology
- Epidemiology of gallbladder cancer
- Incidence of gallbladder cancer in India
- Mortality
- Correlation between gallstones and gallbladder cancer
- Cause of gallstone formation
- The upset of microbiome
- Effect of estrogen in gallstone formation
- Obesity and gallstone
- Age and gender
- Contraction of gallbladder
- Carbohydrate metabolism and diabetes
- Rapid weight loss
- Complications of gallstones
- Inflammation of the gallbladder (acute cholecystitis)
- Jaundice
- Infection of the bile ducts (acute cholangitis)
- Acute pancreatitis
- Gallbladder cancer.
- Gallstone ileus
- Current treatment and therapies for gallstone disease
- Major challenges of gallstones and gallbladder cancer
- 15 Application of computational approaches for the drug discovery of cholesterol gallstone disease: identification of new f...
- Methods
- Protein preparation
- Ligand preparation
- E-pharmacophore modeling and screening
- Receptor grid generation, molecular docking, and free binding energy calculation (MM-GBSA) calculations
- In silico ADMET prediction
- Molecular dynamics simulations
- Results and discussion
- E-pharmacophore generation and virtual screening
- Molecular docking and MM-GBSA calculations
- ADMET prediction
- Molecular dynamics
- Glossary
- Index
- Back Cover.
- Notes:
- Description based on publisher supplied metadata and other sources.
- Part of the metadata in this record was created by AI, based on the text of the resource.
- ISBN:
- 9780443160998
- 0443160996
- OCLC:
- 1427068120
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