Malformations of the nervous system / volume editors, Harvey B. Sarnat and Paolo Curatolo.

Format:

Book

Contributor:

Sarnat, Harvey B.

Curatolo, Paolo.

Series:

Handbook of clinical neurology ; v. 87.

Handbook of clinical neurology ; 3rd ser., v. 87

Language:

English

Subjects (All):

Nervous system--Abnormalities.

Nervous system.

Neurology.

Physical Description:

1 online resource (689 p.)

Place of Publication:

Edinburgh ; New York : Elsevier, 2008.

Language Note:

English

Summary:

This volume deals with brain development malformations of the central nervous system, showcasing a unique approach that furthers research through systematic integration of exciting new developments from fields including molecular genetics, neuroimaging, and neuropathology. By integrating data and research from these disciplines, better conceptualization of the mechanisms of the developmental processes is achieved. Clinicians will find invaluable insights into complex issues, including midline hypoplasias, disorders of segmentation of the neural tube, and hamartomatous disorders of c

Contents:

Front Cover; Malformations of the Nervous System; Copyright Page; Handbook of Clinical Neurology 3rd Series; Foreword; Preface; List of contributors; Contents; Section I: Specific malformations using the new integrative classification; Revised classification; Chapter 1: Axes and gradients of the neural tube for a morphological/molecular genetic classification of nervous system malformations; 1.1.1. Axes of the neural tube and gradients of genetic expression; 1.2. Upregulation/downregulation versus overexpression/underexpression; 1.3.1. Longitudinal axis

1.6. Scheme of classification of central nervous system malformations1.7. Conclusions; Midline hypoplasias; Chapter 2: Holoprosencephaly; 2.3.5. Newer classification schema; 2.4.2. Genetic causes; 2.4.4. Nodal/TGFbeta pathway; 2.4.5. Other gene mutations; 2.4.6. Genotype-phenotype correlation; 2.4.7. Environmental causes; 2.5.2. Midline dorsal cyst; 2.5.3. Cortical gyral abnormalities; 2.5.4. White matter abnormalities; 2.5.5. Other cerebral anomalies; 2.5.7. Middle interhemispheric variant; 2.5.8. Neuroimaging technical approaches; 2.5.9. Fetal neuroimaging; 2.7. Clinical manifestations

2.7.1. Craniofacial anomalies2.7.2. Developmental dysfunction and behavior; 2.7.3. Seizures and epilepsy; 2.7.4. Endocrinopathies; 2.7.5. Temperature dysregulation; 2.7.6. Microcephaly; 2.7.7. Dorsal cyst and hydrocephalus; 2.7.8. Motor dysfunction; 2.8. Conclusion; Chapter 3: Septo-optic-pituitary dysplasia; 3.4.2. The identification of relevant cerebral anomalies; Chapter 4: Rhombencephalosynapsis; 4.3. The confines of rhombencephalosynapsis defined by neuroimaging; 4.4.6. Holoprosencephaly; 4.4.8. Neocortical dysplasia; 4.7. Inherited disorders

Chapter 5: Embryology and malformations of the forebrain commissures5.7. Genetics of callosal agenesis; 5.9.4. Hemimegalencephaly; 5.9.8. Association of callosal agenesis with metabolic diseases; Disorders of segmentation of the neural tube; Chapter 6: Disorders of segmentation of the neural tube: Chiari malformations; 6.3.3. Hydromyelia and aqueductal atresia in Chiari malformations; 6.7. Historical note; Chapter 7: Disorders of segmentation of the neural tube: agenesis of selective neuromeres; 7.3. Agenesis of isolated neuromeres; Chapter 8: Cerebellar hypoplasias

8.1.6. Classification of cerebellar malformations8.4.2. Cerebello-oculo-renal and related syndromes; Hamartomatous disorders of cellular lineage; Chapter 9: Tuberous sclerosis; 9.3. Molecular genetics; 9.4.3. Genotype/phenotype correlations; 9.6.4. Lungs; 9.7. Treatment; Chapter 10: Hemimegalencephaly syndrome; 10.3. Pathogenesis of neurocutaneous syndromes; 10.3.1. Classification; 10.7. Associated hemimegalencephaly; 10.7.1. With neurocutaneous syndromes; 10.8.1. Imaging features; References; Disorders of radial neuroblast migration and cerebral cortical architecture

Chapter 11: Periventricular nodular heterotopia

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-283-60938-X

9786613921833

0-08-055984-0

OCLC:

811507365