Translational medicine in CNS drug development / edited by George G. Nomikos and Douglas E. Feltner.

Format:

Book

Author/Creator:

Nomikos, George G.

Contributor:

Nomikos, George G., editor.

Feltner, Douglas E., editor.

Series:

Handbook of behavioral neuroscience ; Volume 29.

Handbook of behavioral neuroscience ; Volume 29

Language:

English

Subjects (All):

Neuropsychopharmacology.

Drug development.

Central Nervous System Agents.

Drug Development.

Translational Research, Biomedical.

Medical Subjects:

Central Nervous System Agents.

Drug Development.

Translational Research, Biomedical.

Physical Description:

1 online resource (460 pages).

Place of Publication:

London, England : Academic Press, 2019.

Summary:

Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders.Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans.- Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development- Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders- Includes chapters written by international experts from industry and academia

Contents:

Translating animal models of obesity and diabetes to the clinic / B.M. Geiger and E.N. Pothos

Giomarker-guided drug development for better defined early patient studies and clinical trial efficiency / Aldemar Degroot

Modeling and simulation in the translational pharmacology of CNS drugs / Elizabeth C. De Lange and Peter Bonate

Functional measurements of central nervous system drug effects in early human drug development / Joop van Gerven

Experimental medicine approaches in CNS drug development / Jeffrey Paul

New approaches in translational medicine for Phase I clinical trials of CNS drugs / Matthew Macaluso, Michael Krams, Jonathan Savitz, Wayne C. Drevets, and Sheldon H. Preskorn

Translational approaches for antidepressant drug development / Gerard J. Marek

Biomarker opportunities to enrich clinical trial populations for drug development in schizophrenia and depression / Bruce J. Kinon

PET occupancy and competition in translational medicine and CNS drug development / Paul Cumming and Gerhard Gründer

Stable isotope labeling kinetics in CNS translational medicine : introduction to SILK technology / Randall J. Bateman ... [et. al.]

Applications of neurophysiological biomarkers in CNS drug development : focus on psychoses / Yash B. Joshi, Melissa A. Tarasenko, and Gregory A. Light

Heart rate variability as a translational biomarker for emotional and cognitive deficits / Bart A. Ellenbroek, Meyrick Kidwell, Joyce Colussi-Mas, and Jiun Youn

Drug discovery in psychiatry : time for human genome-guided solutions / Andreas Papassotiropoulos and Dominique J.-F. de Quervain

Use of cognition to guide decisions about the safety and efficacy of drugs in early-phase clinical trials / Paul Maruff

Digital biomarkers in clinical drug development / Amir Kalali, Sarah Richerson, Emilia Ouzunova, Ryan Westphal, and Bradley Miller

Lessons learned from public private partnerships and consortia : the ADNI paradigm / Enchi Liu

Regulatory perspectives on the use of biomarkers and personalized medicine in CNS drug development : the FDA viewpoint / Mathangi Gopalakrishnan and Jogarao V.S. Gobburu

Regulatory considerations for the use of biomarkers and personalized medicine in CNS drug development : a European perspective / Eamon O'Loinsigh and Anjana Bose

Regulatory science objectives and biomarker qualification through public-private partnerships are critical to delivering innovative treatments for CNS diseases / Diane T. Stephenson and Stephen P. Arnerić

The assessment of cognition in translational medicine : a contrast between the approaches used in Alzheimer's disease and major depressive disorder / John E. Harrison and Suzanne Hendrix

Translational medicine strategies in drug development for neurodevelopmental disorders / Siddharth Srivastava, Mustafa Sahin, and Lisa Prock

Translational medicine strategies in drug development for mood disorders / Zihang Pan, Radu C. Grovu, and Roger S. McIntyre

Translational medicine strategies in Alzheimer's disease drug development / Veronika Logovinsky

Experimental medicine models in generalized anxiety disorder and social anxiety disorder / David S. Baldwin and Ayman Abou-Aisha

Translational medicine strategies in PTSD drug development / Dan J. Stein, Willie Daniels, and Brian H. Harvey

Translating neurobiology into practice in tobacco, alcohol, drug, and behavioral addictions / Benjamin Srivastava and Mark S. Gold

Translational medicine strategies for drug development for impulsive aggression / Emil F. Coccaro, Royce Lee, and Neal G. Simon

Hypothesizing major depression as a subset of remard deficiency syndrome (RDS) linked to polymorphic reward genes ; considerations for translational medicine approaches for future drug development

Traveling through the storm : leveraging virtual patient monitoring and artificial intelligence to observe, predict, and affect patient behavior in CNS drug development / Adam Hanina and Laura Shafner.

Notes:

Description based on print version record.

ISBN:

0-12-803164-6

0-12-803161-1