Clinical and Laboratory Medicine Textbook / edited by Marcello Ciaccio.

Format:

Book

Author/Creator:

Ciaccio, Marcello.

Language:

English

Subjects (All):

Medicine.

Endocrinology.

Medicine--Research.

Biology--Research.

Biology.

Biochemistry.

Clinical Medicine.

Biomedical Research.

Biological Chemistry.

Local Subjects:

Clinical Medicine.

Endocrinology.

Biomedical Research.

Biological Chemistry.

Physical Description:

1 online resource (719 pages)

Edition:

1st ed. 2023.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2023.

Summary:

This textbook describes several diseases and clinical conditions, from physiopathological mechanisms to main clinical pictures, highlighting the importance of laboratory medicine, with the aim to provide the necessary tools for guiding correct laboratory findings interpretation. Indeed, it is now widely recognized that laboratory medicine has a pivotal role in clinical medicine, significantly influencing clinical decisions. Thus, it is crucial to understand and use laboratory data appropriately. This book has the great advantage of describing each topic exhaustively in order to facilitate its understanding. Specifically, it describes both diseases with a high incidence in the population, such as Diabetes Mellitus, Cardiovascular Diseases, Dyslipidemias, and Autoimmune Diseases, as well as rare diseases, such as Hereditary Metabolic Diseases. In addition, unusual topics are treated, such as Clinical Biochemistry of the Mind, as well as hot topics, such as Biological Drugs, Biobanks, Health Technology Assessment, and Omics Sciences. Finally, the book includes a chapter on the new health emergency, the SARS-CoV-2 pandemic. Two appendices are provided at the end of the book: a table summarizing the reference range and decisional cut-off for the main laboratory parameters and instructions on performing a venous blood sample. The book will be an invaluable tool for medical and biomedical students, as well as for practitioners. This book is a translation of an original Italian edition. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation.

Contents:

1 The role of laboratory medicine in the clinical context

2 The laboratory diagnostic process

3 Elements of biomedical laboratory organization

4 The role of statistics in laboratory medicine

5 Elements of metrology

6 The pre-analytical phase

7 The quality of the laboratory result: SOURCES OF VARIABILITY, METHOD OF ASSESSMENT AND ESTIMATION OF THEIR CLINICAL IMPACT

8 Principles of Immunochemistry

9 General information on laboratory tests and biomarkers

10 Enzymes and their clinical use

11 Liver: from biochemistry to clinical biochemistry

12 Protein diagnostics

13 Biomarkers of the nutritional state

14 Dyslipidemia

15 Hematological diagnostics

16 Immunohematology

17 Hemostasis

18 Kidney

19 Physical, Chemical and morphological urine examination

20 Hydroelectrolytic disorders

21 Blood gas analysis

22 Cardiac biomarkers

23 Stroke biomarkers

24 Thrombophilia

25 Endocrine system

26 Diabetes mellitus: from definition to therapy

27 Diabetes mellitus: the role of the laboratory

28 Metabolic syndrome

29 Hypoglycemia

30 The role of laboratory in pregnancy

31 Hereditary metabolic diseases

32 Hyperphenylalaninemia, thyrosinemia, glycogenosis, hyperammoniemia

33 Circulating biomarkers in oncology: areas of application, critical issues and perspectives

34 Liquid biopsy

35 Biological fluids

36 Laboratory diagnostics of autoimmune diseases

37 Laboratory diagnostics in allergic diseases

38 Biomarkers of bone remodeling

39 Alzheimer's disease and other neurodegenerative dementias

40 In vivo clinical biochemistry

41 Clinical biochemistry of the mind

42 Clinical molecular biology

43 Fever of unknown origin

44 Biomarkers of inflammation

45 Biomarkers of sepsis

46 Laboratory medicine and physical exercise

47 Clinical biochemistry of the physical exercise

48 Preoperative laboratory tests

49 The laboratory in urgency/emergency

50 Biological drugs

51 Mass spectrometry in clinical biochemistry and laboratory medicine

52 Toxicology and analytical pharmacology

53 Pharmacotoxicology of substances of abuse

54 Applications of “omics” sciences in the laboratory

55 Covid-19

56 From aging to healthy longevity: from an oxymoron to an hendiadys. Innovation in Medicine including Predictive Medicine and Laboratory Medicine approaches

57 Biobanks of biomedical interest

58 Health technology assessment in laboratory medicine.-APPENDIX A - RECOMMENDATIONS FOR THE APPROPRIATE VENOUS BLOOD COLLECTION.-APPENDIX B - TABLE OF REFERENCE AND DECISIONAL VALUES OF THE MAIN BIOMARKERS.

ISBN:

9783031249587

3031249585

OCLC:

1424751881