Updates on Clostridioides difficile in Europe : Advances in Microbiology, Infectious Diseases and Public Health Volume 18 / edited by Paola Mastrantonio, Maja Rupnik.

Format:

Book

Contributor:

Mastrantonio, Paola, editor.

Rupnik, Maja, editor.

Series:

Advances in Microbiology, Infectious Diseases and Public Health, 2365-2683 ; 1435

Language:

English

Subjects (All):

Medical microbiology.

Diseases.

Microbiology.

Medical Microbiology.

Local Subjects:

Medical Microbiology.

Diseases.

Microbiology.

Physical Description:

1 online resource (X, 362 p. 28 illus., 25 illus. in color.)

Edition:

2nd ed. 2024.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2024.

Summary:

This fully updated second edition outlines the currently available clinical, epidemiological and experimental data on Clostridioides difficile infections(CDI) with special emphasis on studies and results achieved in Europe. The incidence and severity of CDI has increased significantly over the last decade, and the book explains why C. difficile, recently reclassified as Clostridioides difficile, remains a significant challenge, also from economic perspective, to health care systems all over the world. The different reservoirs of this ubiquitous microorganism are reviewed as well as the different factors contributing to its virulence, such as toxins and biofilm formation. The rapid evolution of antibiotic resistance is clearly a concern and in a specific way can influence the CDI epidemiology. Additionally, new emerging strains and comparative genomics studies are taken into consideration for their relevance from epidemiological and evolutionary point of view. The book also gives an overview on diagnostics, therapy and surveillance, all of which are still challenging. Therefore, a closer look is taken on the effect of probiotics as an alternative to antibiotics, for prevention and treatment of CDI. Fecal transplantation from healthy donors, passive immunotherapies and vaccines for patients with recurrences are also discussed in dedicated chapters. New topics included sporulation and membrane vesicles in C. difficile. The book closes with a summary of the history and the achievements of the European Society of Clinical Microbiology and Infectious Diseases Study Group for Clostridium difficile (ESGCD) written by the current and past presidents of the Society. It is the aim of this book to raise awareness on CDI and to disseminate updated information on its prevention, diagnosis and treatment.

Contents:

Economic burden of Clostridioides difficile infection in European countries

The need for European surveillance of CDI.-Diagnostic guidance for C. difficile infections

European practice for CDI treatment

Faecal microbiota transplantation as emerging treatment in European countries 2.0

Probiotics for prevention and treatment of Clostridioides difficile infection

Immunization strategies against Clostridioides difficile

Ribotypes and new virulent strains across Europe

Antibiotic resistances of Clostridioides difficile

Comparative genomics of Clostridioides difficile

An updated view on the cellular uptake and mode-of-action of Clostridioides difficile toxins

Clostridioides difficile biofilm

Clostridioides difficile sporulation

Membrane vesicles of C.difficile and other Clostridial species

Non-human C.difficile reservoirs and sources: animals,food, environment

The ESCMID Study Group for Clostridioides difficile : history, role and perspectives.

Notes:

Includes bibliographical references.

ISBN:

3-031-42108-6