Regenerative Medicine and Brain Repair / edited by Philip V. Peplow, Bridget Martinez, Thomas A. Gennarelli.

Format:

Book

Contributor:

Peplow, Philip (Philip V.), editor.

Martinez, Bridget, editor.

Gennarelli, Thomas A., editor.

Series:

Stem Cell Biology and Regenerative Medicine, 2196-8993 ; 75

Language:

English

Subjects (All):

Nervous system--Regeneration.

Nervous system.

Regenerative medicine.

Stem cells.

Biomedical engineering.

Biomaterials.

Regeneration and Repair in the Nervous System.

Regenerative Medicine and Tissue Engineering.

Stem Cell Biology.

Biomedical Engineering and Bioengineering.

Local Subjects:

Regeneration and Repair in the Nervous System.

Regenerative Medicine and Tissue Engineering.

Stem Cell Biology.

Biomedical Engineering and Bioengineering.

Biomaterials.

Physical Description:

1 online resource (349 pages)

Edition:

1st ed. 2024.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2024.

Summary:

This book presents the latest knowledge, trends, and advances in cell transplantation and innovations in developing microspheres, 3D biomaterial constructs to enhance transfer, and cell survival to specific regions of the brain. Neurodegenerative diseases and brain injury are increasing. Medications currently only temporarily reduce some of the symptoms but do not cure or delay progression of the disease. Development of effective treatments dramatically improves the independent living and quality of life of patients. Cell transplantation strategies offer an approach to facilitating brain repair, but efficacy is often limited by low in vivo survival rates of cells that are injected in suspension. Transplanting cells that are attached to or encapsulated within a biomaterial construct has the advantage of maintaining cell-cell and cell-material interactions and improving cell survival in vivo. Biomaterials that have been used in preclinical studies to assist with in vivo cell transfer and survival include heparin-chitosan microspheres, poly(lactic-co-glycolic acid) microspheres, RADA 16 microspheres, poly(desaminotyrosyl tyrosine ethyl ester carbonate) microscale scaffolds, carbon nanotubes, collagen-chitosan scaffolds, poly(L-lactic acid) scaffolds, agarose hydrogels, gelatin methacrylate hydrogels, and agarose micro-columns with an extracellular matrix interior. Incorporating growth factors (e.g., glial-derived neurotrophic factor, neurotrophin 3) into the biomaterial constructs increased cell survival and incorporation into the host tissue. International experts in the fields of both experimental and clinical neurological research contribute chapters to this book and discuss the latest achievements in cell transplantation and matrix-assisted cell transfer/survival technologies for diseases such as Alzheimer’s disease, Parkinson’s disease, and brain injuries such as stroke and traumatic brain injury. It is envisaged that research findings in experimental animal models of Alzheimer’s disease, Parkinson’s disease, traumatic brain injury, and stroke promote clinical trials using biomaterial-assisted transfer of cells.

Contents:

Initiating and Facilitating Brain Repair: Factors, Principles, and Mechanisms

Strategies to Upgrade the Stem Cell Application for Brain Transplantation

Neural Stem Cell Intervention in Traumatic Brain Injury

Neurotrophic Factors in Parkinson’s Disease: Clinical Trials

Emerging Nanotechnology for the Treatment and Diagnosis of Parkinson’s Disease (PD) and Alzheimer’s Disease (AD)

Poly(Butyl Cyanoacrylate) Nanoparticles deliver β-Nerve Growth Factor to the Brain after Traumatic Brain Injury

The Significance of Biomaterials in Stem Cell-Based Regenerative Medicine

Endogenous in situ Tissue Regeneration using Inductive Bioscaffolds after Acute Brain Injury

Alginate Nanofibre Scaffolds for Amyotrophic Lateral Sclerosis

Developing High-Fidelity in vitro Models of Traumatic Brain Injury to Test Therapeutic Biomaterials

Challenges and Future Perspectives of Using Bioactive Scaffolds in Brain Repair.

Notes:

Includes bibliographical references and index.

Other Format:

Print version: Peplow, Philip V. Regenerative Medicine and Brain Repair

ISBN:

9783031497445