Fungi Bioactive Metabolites : Integration of Pharmaceutical Applications / edited by Sunil Kumar Deshmukh, Jacqueline Aparecida Takahashi, Sanjai Saxena.

Format:

Book

Contributor:

Deshmukh, S. K. (Sunil K.), editor.

Takahashi, Jacqueline Aparecida, editor.

Saxena, Sanjai, editor.

Language:

English

Subjects (All):

Medicine--Research.

Medicine.

Biology--Research.

Biology.

Drug delivery systems.

Molecular biology.

Molecular ecology.

Cytology.

Biomedical Research.

Drug Delivery.

Molecular Biology.

Molecular Ecology.

Cell Biology.

Local Subjects:

Biomedical Research.

Drug Delivery.

Molecular Biology.

Molecular Ecology.

Cell Biology.

Physical Description:

1 online resource (759 pages)

Edition:

1st ed. 2024.

Place of Publication:

Singapore : Springer Nature Singapore : Imprint: Springer, 2024.

Summary:

This book presents the exploration and exploitation of various bioactive metabolites obtained from fungi isolated from diverse habitats for pharmaceutical applications. Various fungal sources have been brought under one umbrella ranging from endophytes, marine fungi, endolichenic fungi to fungi existing in the extremophilic conditions like desert and Antarctica and Artic environment. The book tries to cover maximally the range of the pharmaceutical applications wherein these bioactive agents from fungi have been exploited or are in the clinical pipelines and primarily include antibacterial, antifungal, antibiofilm, anticancer, antioxidant, autoimmunological, anti-inflammatory, and anti-thrombotic diseases. The book further emphasizes on the novel strategies to screen or enhance secondary metabolite production. Some other topics includes peptides, nonpeptides drugs, pigments, and enhancement of production of Echinocandin and Kojic acid. The role of bioinformatics in drug discovery and biotransformations have also been discussed. This book is going to be a comprehensive treatise and a valuable source for mycologists, biotechnologists, microbiologists, biotechnologists, and undertaking research in pharmaceutical sector as well as academia in setting up their research aspirations for using fungi in the process of drug discovery and development. .

Contents:

Part I: Bioactive Compounds from Endophytic Fungi

Chapter 1. Recent Advances in Pharmaceutically Important Compounds from Endophytic Fungi

Chapter 2. Pharmaceutically Important Compound Produced by Endophytic Fungi Having Anti-Infective Activity

Chapter 3. Fungal Endophytes: An Accessible Natural Repository for Discovery of Bioactive Compounds

Part II: Endolichenic Fungi: A Source of New Chemical Entities

Chapter 4. Endolichenic Fungi as a Source of Pharmaceutically Active Compounds

Chapter 5. Endolichenic Fungi, an Emerging Source of Bioactive Compounds: A Pharmaceutical Perspective

Part III: Marine Fungi as a Source of Medicinal Compounds

Chapter 6. Antibiofilm Metabolites from Sponge-derived Aspergillus, Penicillium, and Fusarium for the Antibiotic Pipeline

Chapter 7. Marine Fungi as a Bioresource of Medicinal Entities

Chapter 8. Natural Bioactive Products from Marine Fungi against Bacterial Infection. Part IV: Fungi as a Bioresource of Pharmacologically Active Agents

Chapter 9. Penicillium: A Treasure-Trove for Antimycobacterial and Antioxidant Metabolites

Chapter 10. Metabolites from Fungi: a Promising Source of Lead Compounds against Cancer

Chapter 11. Edible Mushrooms Substances as Natural Prevention in Autoimmunological Diseases

Chapter 12. New Antifungal Drugs: Discovery and Therapeutic Potential

Chapter 13. Fungal Enzyme Inhibitors: Potent Repository of Lead Compounds to Curb Cancer

Chapter 14. Bioactive Metabolites from Fungi with Anti-Inflammatory and Anti-Thrombotic Properties; Current Status and Future Perspectives for Drug Development

Chapter 15. Progress in the Development of Fungal Metabolites as New Drugs for Human Mycoses

Part V: Fungi from Extremophilic Environment/Unique Ecosystems

Chapter 16. Uncovering the Desert Fungal Enigma: An Attractive Resource for Biopharmaceuticals

Chapter 17. Bioactive Metabolites Produced by Fungi Present inAntarctic, Arctic and Alpine Ecosystems

Part VI: Novel Strategies to Screen or Enhance Secondary Metabolite Production

Chapter 18. Enhancing Chemical Diversity of Fungal Secondary Metabolite by OSMAC Strategy

Chapter 19. Epigenetic Regulation of Fungal Secondary Metabolites for the Enhancement of Therapeutically Active Compounds

Chapter 20. Strategies for Enhancing the Production of Echinocandin

Part VII: Other by Products of Fungal Metabolism with Medicinal Applications

Chapter 21. Fungal Pigments: Applications and Their Medicinal Potential

Chapter 22. A Brief Insight into Peptide and Non-Peptide Drugs of Fungal Origin

Chapter 23. Kojic Acid from Aspergillus wentii: A Journey from Isolation to Application

Part VIII: Bioinformatics and Fungal Biotransformations in Pharmaceutical Drug Development

Chapter 24. How Does Bioinformatics Play a Role in Fungal Drug Discovery?

Chapter 25. Fungal Biotransformation of Steroids: History, Current Status, and Future Prospects. .

Notes:

Includes bibliographical references.

ISBN:

981-9956-96-X