Syncytia: Origin, Structure, and Functions / edited by Malgorzata Kloc, Ahmed Uosef.

Format:

Book

Author/Creator:

Kloc, Malgorzata.

Contributor:

Uosef, Ahmed.

Series:

Results and Problems in Cell Differentiation, 1861-0412 ; 71

Language:

English

Subjects (All):

Cell differentiation.

Developmental biology.

Stem cells.

Cytology.

Cell Differentiation.

Developmental Biology and Stem Cells.

Stem Cell Biology.

Cell Biology.

Local Subjects:

Cell Differentiation.

Developmental Biology and Stem Cells.

Stem Cell Biology.

Cell Biology.

Physical Description:

1 online resource (480 pages)

Edition:

1st ed. 2024.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2024.

Summary:

This book gives a current overview on the development, origin, structure, and functions of germline and somatic cell syncytia during embryogenesis and organogenesis. It also reviews pathogen-induced syncytia and the role of syncytial cells in cancer development. The book covers the following topics: germline syncytia, evolution, function and structure; syncytia in embryogenesis and development; the role of somatic cell fusion in fungi, specialized somatic tissues, host defense and adaptation; syncytia induced by viruses and parasites; syncytia and circulating hybrid cells in cancer and other pathological conditions; It also discusses how the genomic adaptations of microorganisms to extreme habitats can prompt the evolution of mononuclear and multinucleate/syncytial cells. The book offers a fresh outlook on syncytia's role in various processes: embryogenesis, organogenesis, adaptation, host defense, and development of specialized tissues. It highlights the importance of syncytia under physiological and pathological conditions.

Contents:

Part I. Germline Syncytia, Evolution, Function, and Structure

Chapter 1. The Ancient Origin and Function of Germline Cysts

Chapter 2. Female Germline Cysts in Animals: Evolution and Function

Chapter 3. Germline and Somatic Cell Syncytia in Insects

Part II. Syncytia in Embryogenesis and Development

Chapter 4. Reshaping the Syncytial Drosophila Embryo with Cortical Actin Networks: Four Main Steps of Early Development

Chapter 5. Cell-Mediated Branch Fusion in the Drosophila Trachea

Chapter 6. Trophoblast Syncytialization: A Metabolic Crossroads

Chapter 7. Early Syncytialization of the Ovine Placenta Revisited

Chapter 8. Syncytia in Utricularia: Origin and Structure

Part III. Fungal and Somatic Cell Syncytia and Genomic View of Extremophiles as the Ancestral Precursors of Eukaryotic Syncytia

Chapter 9. Syncytial Assembly Lines: Consequences of Multinucleate Cellular Compartments for Fungal Protein Synthesis

Chapter 10. Ancestors in The Extreme: A Genomics View of Microbial Diversity in Hypersaline Aquatic Environments

Chapter 11. Somatic Cell Fusion in Host Defense and Adaptation

Chapter 12. Osteoclasts at Bone Remodeling: Order from Order

Chapter 13. Muscle Progenitor Cell Fusion in the Maintenance of Skeletal Muscle

Part IV. Virus- and Parasite- Induced Syncytia

Chapter 14. Virus-Induced Cell Fusion and Syncytia Formation

Chapter 15. HIV-1 Induced Cell-to-Cell Fusion or Syncytium Formation

Chapter 16. Relevance of the Entry by Fusion at the Cytoplasmic Membrane vs. Fusion After Endocytosis in the HIV and SARS-Cov-2 Infections

Chapter 17. Mathematical Modeling of Virus-Mediated Syncytia Formation: Past Successes and Future Directions

Chapter 18. Syncytium Induced by Plant-Parasitic Nematodes

Part V. Cell Fusion and Syncytia in Cancer

Chapter 19. Mechanisms of Cell Fusion in Cancer

Chapter 20. Cell Fusion and Syncytia Formation in Cancer

Chapter 21. The Hallmarks of Circulating Hybrid Cells.

Other Format:

Print version: Kloc, Malgorzata Syncytia: Origin, Structure, and Functions

ISBN:

3-031-37936-5