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Regulation of Pre-Messenger RNA splicing / Douglas L. Black.
- Format:
- Video
- Author/Creator:
- Black, Douglas L., author.
- Language:
- English
- Subjects (All):
- Eukaryotic cells.
- Genetic transcription.
- Physical Description:
- 1 streaming video file (31 min.) : sound, color
- Place of Publication:
- London, England : Henry Stewart Talks Ltd, 2007.
- System Details:
- video file
- Contents:
- The Regulation of Pre-messenger RNA Splicing
- mRNAs are transcribed as precursor molecules
- mRNA must undergo RNA processing reactions
- Pre-mRNA splicing
- The signals for splicing RNA are at the intron ends
- Splicing proceeds by a two-step pathway
- Splicing chemistry
- Pre-mRNAs contain multiple exons and introns
- The spliceosome
- Structures of the spliceosomal snRNAs
- The spliceosome assembles from snRNPs
- The mature catalytic spliceosome
- Minor class introns
- Two features that affect splice site choice
- The early choice of splice sites to pair
- Additional controls on spliceosome assembly
- A typical mammalian gene
- Exon definition
- SR proteins
- SR proteins mediate the activity of ESEs
- Mutations in splice sites
- Human disease mutations that alter splicing
- Alternative splicing can produce diverse proteins
- Complex transcription units
- The fibronectin gene
- Patterns of alternative splicing
- Alternative splicing generates protein diversity
- The Drosophila DSCAM receptor
- Gene number and complexity of the organism
- More than ESE's
- Somatic sexual development in the fruit fly
- Sex-lethal is a sequence-specific RNA BP
- The female Sxl protein regulates itself and Tra
- Tra exon 2 has two possible 3' splice sites.
- The upstream Tra 3' splice site
- The female specific protein Tra is splicing regulator
- Doublesex exon 4 contains a weak 3' splice site
- The doublesex ESEs are dependent on Tra
- Male and female mRNAs of Dsx produce TFs
- Splicing regulation in vertebrates
- Clusters of RNA elements
- Many RNA binding proteins regulate splicing
- Alternative splicing in the nervous system
- The electrical properties of K+ channels
- Cochlear hair cells
- Some splicing regulators are tissue specific
- Widely expressed splicing regulators
- Problems for the future.
- Notes:
- Description based on publisher supplied metadata and other sources.
- Retrieved April 10, 2024, from https://hstalks.com/bs/662/.
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