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RNA polymerase II general transcription machinery / Michael Hampsey.
- Format:
- Video
- Author/Creator:
- Hampsey, Michael, author.
- Language:
- English
- Subjects (All):
- Eukaryotic cells.
- Genetic transcription.
- Physical Description:
- 1 streaming video file (41 min.) : sound, color
- Place of Publication:
- London, England : Henry Stewart Talks Ltd, 2020.
- System Details:
- video file
- Contents:
- Intro slide
- "Central Dogma" of molecular biology
- Eukaryotic RNA polymerases I, II & III
- Introduction to transcription
- Fundamental questions (1)
- Pol II machinery: Overview of topics (1)
- The RNA polymerase "promoter"
- Pol II machinery: Overview of topics (2)
- Pol II core promoter elements
- CpG islands as "proximal" promoter elements
- Summary: Core promoter elements
- Pol II machinery: Overview of topics (3)
- Enhancer elements
- Enhanceosome
- UAS elements (yeast)
- Silencer elements
- URS elements
- Pol II machinery: Overview of topics (4)
- Discovery of the GTFs (1)
- Discovery of the GTFs (2)
- The GTFs of RNA Polymerase II
- Assembly of the pol II transcription PIC
- The GTFs are loosely analogous to sigma factor
- TFIID
- TBP
- TAFs
- TAF functions
- TFIID: 3D structure
- Class II promoters
- TBP-less TAF complexes
- TLFs
- TFIIA
- TFIIB
- TFIIB: inserts into Pol II active center
- TFIIF
- TFIIE
- TFIIH
- TFIIH: Clinical importance
- Fundamental questions (2)
- Pol II machinery: Overview of topics (5)
- Pol II
- Yeast Pol II - 3D structure (10 subunit)
- Yeast RNAP II - 12 subunit structure
- A marvellous machine for making messages - A. Klug
- The pol II CTD
- Regulation of the Pol II CTD
- Pol II machinery: Overview of topics (6)
- Pol II transcription cycle
- Scaffold: facilitates reinitiaiton by Pol II
- Fundamental questions (3)
- Activation by "recruitment"
- Fundamental questions (4)
- Transcriptional repression
- Unanswered questions
- The End.
- Notes:
- Description based on publisher supplied metadata and other sources.
- Retrieved April 10, 2024, from https://hstalks.com/bs/659/.
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