Polycomb epigenetic mechanisms : role of PcG complexes / Prof. Vincenzo Pirrotta.

Format:

Video

Author/Creator:

Pirrotta, Vincenzo, author.

Series:

Henry Stewart talks

Language:

English

Subjects (All):

Epigenesis.

Physical Description:

1 videorecording (23 min., 21 sec.) : sound, color.

Other Title:

Polycomb epigenetic mechanisms

Place of Publication:

London : Henry Stewart Talks Ltd, [2017]

System Details:

video file

Contents:

Introduction

Chromatin silencing

Polycomb mechanisms

Drosophila homeotic genes

Polycomb insufficiency in Pc+/- flies

The sex comb and the Polycomb phenotype

Transcriptional activity and PcG complexes (1)

Transcriptional activity and PcG complexes (2)

PcG complexes

The core of the PRC1 complex is a heterodimer

Both RING and the PCGF contain a RING domain

The core structure of RING and PCGF is similar

The ring heterodimer

PRC1 contains two other important proteins

Chromodomain (1)

Chromodomain (2)

The mammalian PCR1 complex

Variant PRC1 complexes

The PRC2 complex (1)

The PRC2 complex (2)

The PRC complexes

PRC1 and PRC2 act together at target genes (1)

PRC1 and PRC2 act together at target genes (2)

A Drosophila PRE (1)

A Drosophila PRE (2)

PRC1 and PRC2 in the PRE (1)

PRC1 and PRC2 in the PRE (2)

Most PcG complexes bind at CpG islands

PcG complexes and CpG islands

KDM2B recruits PRC1.1 to a CpG island promoter

KDM2B ubiquitylates H2AK119

PRC2 with AEBP2 and JARID2 binds H2AK119ub

Canonical PRC1 binds to H3K27me3

Other mechanisms in PRC2 recruitment

Transcriptional activity and PcG complexes

Recruitment of PRC2 to CpG islands

Dynamic activities of PcG complexes

Thank you.

Notes:

Description based on publisher supplied metadata and other sources.