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Parkinson's disease and transplants / Roger A. Barker.
- Format:
- Video
- Author/Creator:
- Barker, Roger A., author.
- Language:
- English
- Subjects (All):
- Alternative medicine.
- Brain stimulation.
- Physical Description:
- 1 videorecording (61 min., 08 sec.) : sound, color
- Place of Publication:
- London : Henry Stewart Talks, 2020.
- System Details:
- video file
- Contents:
- Intro slide
- The classical pathology of Parkinson's disease
- Treatment strategies in PD
- Criteria for any cell therapy to be used in PD
- Experimental data on neural grafts: summary
- Clinical effects of fetal nigral allografts
- Freed et al trial of neural grafting in PD
- Olanow et al trial of neural grafting in PD: design
- Olanow et al trial of neural grafting: results
- Summary of clinical data on neural allografts in PD
- The issues facing neural grafting in PD
- The real pathology of PD
- Clinical spectrum of signs and symptoms in PD
- Thus the remit for any cell therapy in PD
- Different cells that could be used in PD
- Xenografts
- Obstacle 1: zoonotic infection
- Paradis et al study on PERVs
- Van der Laan et al study on PERVs
- Obstacle 2: risk of rejection
- The CD8 cellular rejection response
- Obstacle 3: functional capacity of xenografts
- Stem cells
- Why consider stem cells for grafting?
- Types of stem cells
- How might stem cells be used in treating PD
- Transplantation of exogenously derived stem cells
- Embryonic neural stem cells (NSCs)
- What must embryonic NSCs be able to do?
- Embryonic NSCs in vitro: growth potential
- Embyonic neural stem cell differentiation in vitro
- Problems with embryonic NSCs: general
- Changes in embryonic NSC behaviour over time
- The problems with their terminal differentiation
- ES cells and dopmainergic differentitiation
- Conclusion on stem cells forming dopamine cells
- Can such cells repair brains?
- Porcine NSC transplant study
- Transplant survival
- Transplant differentiation
- Presence of Dopaminergic cells
- Circuit reconstruction (1)
- Circuit reconstruction (2)
- Functional outcome
- Conclusion on stem cell transplants in PD to date
- Cells for grafting: conclusion
- Where should transplants be placed?
- Summary of data to date
- Nigrostrital circuit reconstruction data to date
- Topography of nigrostriatal dopaminergic projection
- Conclusion on where grafts should be placed
- When should patients be grafted
- The stages of PD and origin of dyskinesais
- The treatment of PD by stage
- Conclusion on when should patients be grafted
- Which patients should be grafted?
- The heterogeneity of PD
- The CamPaIGN study design
- Defining PD heterogeneity
- Motor phenotypes
- Motor phenotypes in the CamPaIGN study
- Cognitive phenotypes
- Cognitive phenotypes in the CamPaIGN study
- Verbal working memory in PD
- fMRI changes with manipulation on VWMT
- But what causes these differences?
- COMT and BDNF
- Comt and BDNF polymorphisms
- A tentative classification of PD
- Conclusion on which patients should be grafted
- Overall conclusion
- Acknowledgements
- Speaker details.
- Notes:
- Description based on publisher supplied metadata and other sources.
- Retrieved April 8, 2024, from https://hstalks.com/bs/235/.
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