Protein networks and analysis of global gene expression / Trey Ideker.

Format:

Video

Author/Creator:

Ideker, Trey, author.

Series:

Henry Stewart talks.

Henry Stewart talks

Language:

English

Subjects (All):

Genetic regulation.

Physical Description:

1 videorecording (46 min., 36 sec.) : sound, color.

Place of Publication:

London : Henry Stewart Talks, 2016.

System Details:

video file

Contents:

Printable Handouts

Navigable Slide Index

Introduction

From protein sequences. . . to protein networks

High throughput protein interactions

ChIP-chip of protein-DNA interactions

Yeast two-hybrid method

Protein interaction data are exponentially growing

Integration of networks with gene expression data

Reconciling protein networks with gene expression

Regulatory pathways of physical interactions

Physical pathways explaining knock-out effects

Ambiguity in many pathway models

Resolving ambiguity through further perturbations

Cytoscape

Comparison of networks from different species

Cross-comparison of networks

Multiple network alignment of three species

Example yeast/worm/fly alignments

Prediction of new protein interactions

40-50% of predictions confirmed

Plasmodium: a network apart?

Plasmodium has low level of conservation

Comparison of networks of different types

Synthetic lethals interactions

Physical pathways to explain genetic interactions

Classical interpretation of genetic interactions

Integration of genetic and physical interactions

"Parallel pathway" relationships in yeast

Genetic linkages between physical pathways

First build the scaffold, then add the details

Acknowledgements.

Notes:

Description based on publisher supplied metadata and other sources.

Retrieved April 12, 2024, from https://hstalks.com/bs/639/.