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PI 3-kinases and lipid messengers / Bart Vanhaesebroeck.
- Format:
- Video
- Author/Creator:
- Vanhaesebroeck, Bart, author.
- Series:
- Henry Stewart talks
- Language:
- English
- Subjects (All):
- Antimitotic agents.
- Cellular signal transduction.
- Physical Description:
- 1 streaming video file (45 min., 18 sec.) : sound, color.
- Place of Publication:
- London : Henry Stewart Talks Ltd, 2020.
- System Details:
- video file
- Contents:
- Introduction
- PI 3-kinase (PI3K)
- Overview
- PI lipids in cell membranes
- PI3Ks basic function
- Inositol lipids are built around the Phosphatidyl-Inositol (PI) building block
- PI3Ks: phosphorylate the 3 position of phosphatidyl-inositol lipids
- 3-PI ≠ IP3
- The PI lipid network
- The PI-network is key in cell biology & signalling
- PI3K lipids & their target proteins
- Mammalian cells contain four distinct 3-phosphoinositides
- Different PI3K lipids have different binding partners
- Class I PI3K lipids bind to PH domains found in a diverse set of molecules
- Akt/PKB Ser/Thr kinase as an example of a PI3K effector cascade
- PI3K enzyme family
- PI3K: a family of enzymes
- Signalling by class I PI3K isoforms
- Class I PI3K signalling
- Take-home messages (1)
- PI3K in disease
- PI3K signalling
- PI3K signalling is often hyperactivated in cancer (1)
- PI3K signalling is often hyperactivated in cancer (2)
- PI3K signalling is often hyperactivated in cancer (3)
- Low dose of PI3Kα inhibitor is effective in PROS
- PI3K isoforms & approved PI3K inhibitors (1)
- PI3Kα-targeted therapy for cancer: 'smart' combination therapy
- PI3K isoforms & approved PI3K inhibitors (2)
- PI3Kδ
- How do PI3Kδ inhibitors work? I. B-cell malignancies (1)
- How do PI3Kδ inhibitors work? I. B-cell malignancies (2)
- How do PI3Kδ inhibitors work? I. B-cell malignancies (3)
- How do PI3Kδ inhibitors work? II. In haem & solid tumours (T cells) (1)
- How do PI3Kδ inhibitors work? II. In haem & solid tumours (T cells) (2)
- Can PI3Kδ and PI3Kγ inhibitors be used to treat solid tumours?
- The changing landscape of PI3K inhibition in cancer - a summary
- Take-home messages (2)
- Thank you!.
- Notes:
- Description based on publisher supplied metadata and other sources.
- Retrieved April 13, 2024, from https://hstalks.com/bs/461/.
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