1 option
Regulation of apoptosis : lessons from Drosophila and their implications for human health and disease / Prof. Hermann Steller - Howard Hughes Medical Institute, The Rockefeller University, USA.
- Format:
- Video
- Author/Creator:
- Steller, Hermann, author.
- Language:
- English
- Subjects (All):
- Apoptosis.
- Drosophila.
- Physical Description:
- 1 videorecording (46 mins., 28 sec.) : sound, color
- Other Title:
- Regulation of apoptosis
- Place of Publication:
- London, England : Henry Stewart Talks Ltd, 2007.
- System Details:
- video file
- Contents:
- Introduction
- Different signals influence apoptosis
- "Gas" and "Brake" model of apoptotic control
- Reaper, Hid and Grim are required for apoptosis
- Reaper, Hid and Grim are key killer genes
- Genetic screen for cell death genes
- Reaper family proteins
- DIAP1 is the target for cell killing by RHGs
- The N-terminus of Reaper, Hid and Grim
- Reaper family proteins contain a conserved motif
- RHG binding in Drosophila & mammals
- Reaper mimetics can disrupt BIR caspase binding
- IAP's and cancer
- Ubiquitination and apoptosis
- Expression of Reaper reduces half life of IAP
- Reaper stimulates DIAP1 auto-ubiquitination
- Dual role of Reaper
- Diap-1 mediated ubiquitination
- diap1 -/- cells don't survive
- RING mutant cells undergo apoptosis
- RING domain restricts pre-Droc protein levels
- DIAP1 prevents inappropriate apoptosis
- Cell proliferation mitogens in apoptotic cells
- Cellular damage results in compensatory growth 1
- Cellular damage results in compensatory growth 2
- Active model of compensatory proliferation
- Undead cells express wg and dpp
- Wg signaling results in cell proliferation
- Model for compensatory proliferation
- Do mitochondria regulate caspases in Drosophila?
- Caspase activation in spermatogenesis
- Spermatid individualization in culture
- Effector caspase-3-like drICE
- Caspase inhibition blocks individualization
- Screen of genes involved in caspase activation
- Cyt c mutations
- Sterility is rescued by Cyt c transgenes
- Cyt-c-d & cyt-c-p rescue fertility
- Cyt-C is required for effector caspase activation
- Proteins required for normal apoptosis
- Cyt-c-d promotes apoptosis
- Apoptosome proteins
- Cyt c is required for apoptosis
- Generation of ARTS deficient mice
- ARTS - summary
- Generation of sept4-null mice
- Why are Sept4-null mice sterile?
- ARTS antagonizes IAPs
- Sperm differentiation in Drosophila and mammals
- ARTS, apoptosis and tumorigenesis
- Acquired characteristics of cancer cells
- Sept4-null mice develop lymphoma
- "Gas" and "Brake" model - summary
- Acknowledgements.
- Notes:
- Description based on: online resource; title from PDF information screen (Henry Stewart Talks Biomedical and Life Sciences Collection, viewed April 12, 2024).
- Retrieved April 13, 2024, from https://hstalks.com/bs/277/.
The Penn Libraries is committed to describing library materials using current, accurate, and responsible language. If you discover outdated or inaccurate language, please fill out this feedback form to report it and suggest alternative language.