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Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurones / Alexei Verkhratsky.
- Format:
- Video
- Author/Creator:
- Verkhratskiĭ, A. N. (Alekseĭ Nestorovich), author.
- Series:
- Henry Stewart talks
- Language:
- English
- Subjects (All):
- Calcium--Physiological effect.
- Calcium.
- Apoptosis.
- Physical Description:
- 1 streaming video file (45 min., 05 sec.) : sound, color.
- Place of Publication:
- London : Henry Stewart Talks Ltd, 2007.
- System Details:
- video file
- Summary:
- Audio-visual presentation : Endoplasmic reticulum ; Calcium signaling ; Intracellular integration ; Calcium waves ; Calcium signal propagation ; Calcium tunnels ; Neuronal signaling ; Intracellular calcium release channels ; Ryanodine receptors (RyR) ; Inositol (1,4,5) trisphosphate receptors (InsP3Rs) ; Endoplasmic reticulum stress ; Neurodegenerative diseases ; Neuronal cell death.
- Contents:
- Introduction
- Calcium signalling: the beginning
- Calcium signalling - the idea is born
- Calcium signalling - early discoveries (1)
- Calcium signalling - early discoveries (2)
- Patch-clamp and fluorescent Ca indicators
- Diversity and versatility of calcium probes
- Patch-voltage-clamp and Ca indicators combined
- Calcium as universal signalling molecule
- Principles of calcium signalling machinery
- The ER and neuronal calcium signalling
- Endoplasmic reticulum - the discovery
- Neuronal ER: morphology and appearance
- Molecular physiology of ER calcium store
- Probing for calcium stores
- Caffeine-induced Ca release - the beggining
- Intracellular origin of caffein-induced Ca release
- A view from the lumen of Ca release
- Concentration dependance and "quantal" behaviour
- Ca-induced Ca release - initial evidence
- Ca-induced Ca release - UT recordings
- Ca-induced Ca release - intraluminal Ca recordings
- CICR is graded by Ca entry
- InsP3-induced Ca release - the beginning
- Activation by neurotransmitters
- Concentration dependence
- The neuronal ER is a functionally single Ca store
- Homogeneity of the ER Ca store (1)
- Homogeneity of the ER Ca store (2)
- Evidence for single vs. separate ER Ca store
- Intraluminal Ca controls ER Ca homeostasis
- Magnitude and velocity of calcium release
- SERCA-mediated Ca uptake
- Molecular basis for [Ca]L-dependent regulation
- Luminal Ca controls ER Ca uptake
- Endoplasmic reticulum and synaptic transmission
- Controlling pre- and post-synaptic Ca signalling
- Presynaptic RyR-mediated Ca release
- Presynaptic expression of CICR mechanism
- Postsynaptic expression of CICR mechanism
- Ca release through InsP3Rs sets cerebellar LTD
- The ER as an integrating signalling organelle
- ER dysfunction and neurodegeneration
- ER and neuropathology
- Chronic changes in ER Ca level trigger cell death
- Neuronal pathology affects releasable Ca content?
- Experimental diabetes effect on ER Ca
- Intraluminal Ca controls the ER signalling functions.
- Notes:
- Description based on publisher supplied metadata and other sources.
- Retrieved April 11, 2024, from https://hstalks.com/bs/93/.
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