Understanding obesity : genes and environment in the determination of body weight / Rudolph L. Leibel.

Format:

Video

Author/Creator:

Leibel, Rudolph L., author.

Language:

English

Subjects (All):

Obesity--Treatment.

Obesity.

Weight loss.

Physical Description:

1 videorecording (1 hr., 04 min., 28 sec.)

Other Title:

Understanding obesity

Place of Publication:

London : Henry Stewart Talks Ltd, 2007.

System Details:

video file

Summary:

Audio-visual presentation : Evolutionary arguments for regulation of body fat ; Gene x gene x environment interactions ; Molecular physiology of control of body weight ; Human monogenic obesities ; Complex genetics of human obesity ; Threshold model for control of body weight ; Bioenergetics of reduced body weight ; Structural plasticity in the CNS systems regulating body fat.

Contents:

Introduction

Why is body weight regulated?

Adiposity - past and present

Gene-environment interactions and body weight

Brain regions that regulate body weight

Leptin secretion is proportional to body fat

Complex CNS interactions in weight regulation

Leptin signaling and monogenic forms of obesity

Mutations in leptin and its receptor

Multiple biological effects of leptin in humans

Mutation of the leptin receptor

POMC and melanocortin receptor mutations

POMC mutation

PC1 mutation

MC4R mutations result in inherited obesity

MC4R mutations cause monogenic obesity

Genetic loci of obesity genes

Obesity genetics are complex

Concordance of obesity - dizygotic twins

Concordance of obesity - monozygotic twins

Obesity genetics of different populations(1)

Obesity genetics of different populations(2)

BMI as a function of age, sex and genotype

Additive effect of obesity genes mutations

Mutations in obesity genes and body fat - mice

Leptin threshold effects

Bioenergetics of reduced body weight

Biological response to changes in leptin levels

Is threshold changeable?

Neurotrophic effects of leptin exposure

Neurotrophic effects of CNTF is similar to leptin's

Investigators

Thanks.

Notes:

Description based on: online resource; title from PDF information screen (Henry Stewart Talks Business & Management Collection, viewed April 11, 2024).

Retrieved April 11, 2024, from https://hstalks.com/bs/560/.