Use of algorithms for high quality diagnostics and handling of patients with autoimmune rheumatic diseases / Allan Wiik.

Format:

Video

Author/Creator:

Wiik, Allan, author.

Language:

English

Subjects (All):

Autoimmune diseases.

Physical Description:

1 streaming video file (39 min.) : digital, mono, SWF file, sound, color

Place of Publication:

London : Henry Stewart Talks Ltd, 2007.

System Details:

video file

Summary:

Audio-visual presentation : Tests to diagnose autoimmune rheumatic diseases ; Parameters to indicate clinical value of test results ; Tests based on different technologies ; Making diagnostics clinically appropriate ; Algorithms for use in family practice and in rheumatology practice ; Detection of early autoimmune disease ; Value for money has to be based on optimal early diagnostic work-up.

Contents:

Introduction

Autoantibodies content as a disease "fingerprint"

Major topics of this lecture

Medical challenges (1)

Medical challenges (2)

Inflammatory rheumatic disease (IRD) diagnostics

Diagnostics/prognostics of IRD

Optimal user-defined needs

Tests used for diagnosis of a disease

Laboratory aspects 2006

Laboratory medicine 2006

Indicating clinical value of test results (1)

Indicating clinical value of test results (2)

Sensitive assays

Example: anti-dsDNA antibodies determination

Screening by indirect immunofluorescence (IIF)

My postulate

Cellular regions: HEp-2 cells

Modern testing platforms: are they better?

Autoantigen arrays

Addressable laser bead immuno-assay

Reading the reactions

Limitations of solid phase assays

Diagnosis vs. differential diagnosis

Criteria-based clinical diagnostics

Ideal clinical and laboratory collaboration (1)

Ideal clinical and laboratory collaboration (2)

Making diagnostics appropriate

Achieving early diagnosis of IRD

Example of an algorithm

Principle of autoimmune test guide

Algorithm for clinical utility

Autoantibody-associated sub-syndromes of IRDs

Autoantibody-associated lupus sub-syndromes

ANA in glomerular lesions of SLE patients

Production of ANA before SLE onset (1)

Production of ANA before SLE onset (2)

Production of antiphospholipids before SLE onset

Genes and autoantibody production in SLE

Infrequent ANAs are important

Scleroderma: survival rates

Anti-centromere associations: limited scleroderma

Anti-Th/To RNP associations: limited scleroderma

Anti-Scl-70 associations: diffuse scleroderma

Anti-RNA pol I associations: diffuse scleroderma

Anti-U3 RNP associations: diffuse scleroderma

Anti-U1RNP associations: overlap scleroderma

Anti-PM/Scl associations: overlap scleroderma

Evidence-based laboratory medicine

Ultimate importance: clinical outcome

Perspectives: health economics

Conclusions (1)

Conclusions (2)

Conclusions (3)

Some references.

Notes:

Description based on publisher supplied metadata and other sources.

Retrieved April 7, 2024, from https://hstalks.com/bs/206/.