Pathways of apoptosis in muscle. 1 / Stephen E. Alway.

Format:

Video

Author/Creator:

Alway, Stephen E., author.

Language:

English

Subjects (All):

Apoptosis.

Physical Description:

1 streaming video file (47 min.) : digital, mono, SWF file, sound, color

Place of Publication:

London : Henry Stewart Talks Ltd, 2018.

System Details:

video file

Summary:

Audio-visual presentation : Introduction and importance of nuclear apoptosis in skeletal muscle ; Loading and nuclear apoptosis of myonuclei and satellite cells ; Apoptosis in muscle with unloading and denervation ; Mitochondrial-induced caspase-dependent signaling ; Id2 signaling and mitochondrial-associated apoptosis ; Cross-talk between intrinsic and extrinsic signaling for apoptosis ; Bax, a key player in mitochondrial-associated apoptotic signaling ; Mitochondrial associated caspase independent signaling ; Exercise as a tool to decrease pro-apoptotic signaling proteins.

Contents:

Introduction

Apoptosis occurs in skeletal muscle

Nuclear apoptosis

Muscle fibers are multinucleated

Nuclear apoptosis in muscle loading

Apoptosis and overload-induced hypertrophy

Overload in aging rats

Stretch-overload in aged quail

Loading causing hypertrophy decreases apoptosis

Hypertrophied muscle from old quails

Mitochondrial apoptosis signal transduction

Quail loading - Bax and Bcl2 protein

Loading-induced regulators of apoptosis (1)

Loading-induced regulators of apoptosis (2)

Apoptotic signaling during muscle wasting

Models of muscle wasting

Sarcopenia

Sarcopenia & apoptosis

Bax/Bcl-2

Denervation-induced muscle wasting

Apoptosis is activated during muscle denervation

Response to apoptotic stimulus

Cytochrome c levels post denervation

Caspase-3 and caspase-9 levels post denervation

PARP levels post denervation

Smac levels post denervation

AIF levels post denervation

p53 levels post denervation

Effects of aging on apoptosis

Unloading/disuse -associated muscle wasting

Apoptosis is activated during hindlimb suspension

Apoptotis in hindlimb suspension (mitochondria)

Apoptosis is activated during muscle regression

BrdU-positive nuclei under lamina

Percent of BrdU-positive nuclei

TUNEL under lamina

TUNEL-positive/BrdU-positive nucleus

Mitochondria-apoptosis in unloading

Nuclear apoptosis and muscle regression

Id2 signaling in apoptosis

Id2 in aging muscles

Hindlimb suspension increases cytoplasmic Id2

Id2 levels in unloaded quail muscles

Relationship of Id2 and apoptosis

Will overexpression of Id2 increase apoptosis?

Annexin V as an early marker of apoptosis

Muscle wasting/unloading

Unloading followed by reloading and apoptosis

XIAP protein

Apoptotic index after hindlimb suspension

Apoptosis signaling in aging-induced sarcopenia

Mitochondrial regulated sarcopenia

Potential model for apoptosis induction

Cross-talk between signaling pathways

Extrinsic and intrinsic signaling pathways

Cross-talk - cell death to mitochondria pathways.

Notes:

Description based on publisher supplied metadata and other sources.

Retrieved April 6, 2024, from https://hstalks.com/bs/186/.