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Targeting cancer : designing drugs against Hsp90 / Gabriela Chiosis.
- Format:
- Video
- Author/Creator:
- Chiosis, Gabriela, author.
- Language:
- English
- Subjects (All):
- Heat shock proteins.
- Physical Description:
- 1 videorecording (51 min., 01 sec.)
- Other Title:
- Targeting cancer
- Place of Publication:
- London : Henry Stewart Talks Ltd, 2007.
- System Details:
- video file
- Summary:
- Audio-visual presentation : Heat shock protein 90 (Hsp90), a target in cancer ; Discovery of the first known Hsp90 inhibitor, geldanamycin ; Use of geldanamycin to understand the role of Hsp90 in malignant transformation ; Discovery of novel Hsp90 inhibitors ; Development and applications of Hsp90 inhibitors.
- Contents:
- Introduction
- Anticancer target: definition
- Hsp90 - an ideal anti-cancer target?
- Geldanamycin - discovery in phenotypic screen
- Tumoricidal activity of ansamycins
- Inhibition of Hsp90-pp60 complex formation
- Hsp90-geldanamycin complex crystal structure
- Geldanamycin blocks Hsp90 biological function
- Mutant p53 requires functional Hsp90
- Transformation-specific effects of Hsp90
- Broad-spectrum effects of Hsp90
- Hsp90 inhibition may affect many cancers
- Hsp90 acts as a "buffer" of transformation
- Are Hsp90 inhibitors a solution to cancer?
- Tumor selectivity on Hsp90 inhibitors
- Validation of Hsp90 as a target
- Ansamycins
- Improved formulations of 17-AAG (1)
- Improved formulations of 17-AAG (2)
- Pharmacodynamic markers
- Radicicols
- ADP inside Hsp90/kinase pocket
- Purine-scaffold Hsp90 inhibitors (1)
- PU3 mimics the biological effects of GM
- Purine-scaffold Hsp90 inhibitors (2)
- Pyrazole derivatives
- Other Hsp90 inhibitors
- Conclusions from small Hsp90 inhibitors use
- Classical pharmacokinetic analysis relevance
- Inhibition of Hsp90 - cytostatic or cytotoxic?
- Limiting factors of anti-cancer potential (1)
- Limiting factors of anti-cancer potential (2)
- Limiting factors of anti-cancer potential (3)
- Hsp90 inhibitors translation to other diseases
- Concluding remarks.
- Notes:
- Description based on: online resource; title from PDF information screen (Henry Stewart Talks Business & Management Collection, viewed April 16, 2024).
- Retrieved April 16, 2024, from https://hstalks.com/bs/351/.
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