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Solid phase peptide synthesis / Stephen B. H. Kent.
- Format:
- Video
- Author/Creator:
- Kent, Stephen B. H., author.
- Language:
- English
- Subjects (All):
- Peptides--Synthesis.
- Peptides.
- Peptides--Therapeutic use.
- Physical Description:
- 1 videorecording (57 min., 04 sec.) : sound, color
- Place of Publication:
- London : Henry Stewart Talks, 2008.
- System Details:
- video file
- Summary:
- Audio-visual presentation: Chemical structure of peptides -- Chemical peptide synthesis -- Classical solution synthesis -- Solid-phase peptide synthesis -- Chemistry of SPPS -- Automated solid-phase peptide synthesis -- Impact of SPPS -- Fundamentals of SPPS -- Synthesis takes place within the beads -- 'Super-elastic' swelling of peptide-resin beads -- Boc chemistry SPPS -- Fmoc chemistry SPPS -- 'Difficult' peptide sequences in SPPS -- Optimized solid-phase peptide synthesis -- Impact on SPPS of modern analytical methods -- Extensions of SPPS & applications of the solid-phase principle -- Scope and limitations of SPPS -- Impact of chemical ligation -- Total synthesis of human lysozyme.
- Contents:
- Introduction
- Peptide synthesis
- Peptide theory of protein structure
- Chemical structure of peptides
- (Chemical) peptide synthesis
- Epochs of chemical peptide synthesis
- Classical solution synthesis
- Protein-derived peptides
- Solid phase peptide synthesis
- Chemistry of SPPS
- SPPS - reaction vessel
- SPPS case study: cecropin A
- SPPS case study: human beta-endorphin
- Automated solid phase peptide synthesis
- Impact of solid phase peptide synthesis
- Fundamentals of SPPS
- Synthesis takes place within the beads
- 'Super-elastic' swelling of peptide-resin beads
- Narrow-line NMR spectra of resin-bound peptides
- Solubilizing effect of attachment to the resin
- Functionalization of the resin support
- Boc chemistry SPPS - protecting group scheme
- Boc chemistry SPPS - cleavable linkers
- Boc chemistry SPPS - protecting groups
- Boc chemistry SPPS - chain extension
- Boc chemistry SPPS - side reactions
- Boc chemistry SPPS - deprotection and cleavage
- Boc chemistry SPPS - HF apparatus
- Boc chemistry SPPS - HF side reactions
- Fmoc chemistry SPPS - protecting group scheme
- Fundamentals of Fmoc chemistry SPPS
- Fmoc chemistry SPPS - cleavable linkers
- Chain extension and deprotection/cleavage
- 'Difficult' peptide sequences in SPPS
- The 'diffculty' is a property of the peptide chain
- Examples of 'difficult' peptide sequences for SPPS
- Effect of disrupting peptide aggregation
- An optimized solid phase peptide synthesis
- Boc SPPS case study: HIV-1 protease
- Boc SPPS case study: DGK(1-25)-thioester
- Optimized Fmoc SPPS
- Fmoc SPPS case study: transmembrane peptide
- Fmoc SPPS case study: FDD(50-95)-amide
- Impact of modern analytical methods on SPPS
- Preparation of large numbers of natural peptides
- Extensions and applications of SPPS
- Scope and limitations of SPPS
- Byproducts accumulate as chain length increases
- Synthesis of HIV-1 protease
- Capability of routine chemical protein synthesis
- Chemical protein synthesis
- Synthesis of transmembrane peptide-thioesters
- Impact of chemical ligation
- Emil Fischer (1852-1919)
- Total synthesis of human lysozyme
- Impact of SPPS
- Bruce Merrifield (1921-2006).
- Notes:
- Description based on publisher supplied metadata and other sources.
- Retrieved April 19, 2024, from https://hstalks.com/bs/932/.
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