1 option
Population structure in genome-wide association studies / Dan Davison.
- Format:
- Video
- Author/Creator:
- Davison, Dan, author.
- Language:
- English
- Subjects (All):
- Disease susceptibility.
- Physiology, Pathological.
- Physical Description:
- 1 videorecording (31 min., 34 sec.)
- Place of Publication:
- London : Henry Stewart Talks Ltd, 2008.
- System Details:
- video file
- Summary:
- Audio-visual presentation: What is population structure? -- The problem of structure in association studies -- Detecting unknown structure -- Mixture modelling, principal components analysis -- Is there a problem? -- Controlling for known structure: matching, family-based designs, stratified testing -- Controlling for unknown structure: genomic control, mixture modelling, principal components, regression modelling.
- Contents:
- Introduction
- Outline
- What is population structure?
- The problem of structure in association studies
- The problem can be worse
- Detecting unknown structure
- Detecting unknown structure: mixture modelling
- Structure: no-admixture model
- Structure: admixture model
- Example of admixture model
- Principal components analysis
- Example of PCA
- Detecting unknown structure using PCA: summary
- PCA example: East Asia
- PCA example: Europe
- Ancestry informative markers (AIMs)
- Unknown strucrure
- Is there a problem? (1)
- Is there a problem? (2)
- A priori known structure
- Sample matching (1)
- Sample matching (2)
- Stratified testing
- Limitations of stratified testing
- Controlling for unknown structure
- Genomic control
- Advantages and disadvantages of genomic control
- Use inferred structure
- Regression modelling
- Structured association (1)
- Structured association (2)
- Structured association: STRAT
- Controlling for unknown structure: PCA
- EIGENSTRAT: simulation study (1)
- EIGENSTRAT: simulation study (2)
- EIGENSTRAT: simulation study (3)
- Simulation study: differentiated SNPs (1)
- Simulation study: differentiated SNPs (2)
- Summary
- Software
- References.
- Notes:
- Description based on: online resource; title from PDF information screen (Henry Stewart Talks Business & Management Collection, viewed April 8, 2024).
- Retrieved April 9, 2024, from https://hstalks.com/bs/870/.
The Penn Libraries is committed to describing library materials using current, accurate, and responsible language. If you discover outdated or inaccurate language, please fill out this feedback form to report it and suggest alternative language.