Plasmacytoid dendritic cells : sensing nucleic acids in viral infection and autoimmunity / Yong-Jun Liu.

Format:

Video

Author/Creator:

Liu, Yong-Jun, (University of Texas MD Anderson Cancer Center, USA), Speaker.

Series:

Henry Stewart talks. Biomedical & life sciences collection. Innate immunity : host recognition and response in health and disease.

Innate immunity : host recognition and response in health and disease, 2056-452X

Language:

English

Subjects (All):

Immunity, Innate.

Medical Subjects:

Immunity, Innate.

Physical Description:

1 streaming video file (25 min.) : sound, color

Place of Publication:

London : Henry Stewart Talks, 2009.

System Details:

video file

Contents:

Contents: Plasmacytoid dendritic cells (pDCs) are important mediators of antiviral immunity through their ability to produce large amounts of type I interferons (IFNs) on viral infection

This function of pDCs is linked to their expression of Toll-like receptor 7 (TLR7) and TLR9, which sense viral nucleic acids within the early endosomes

Exclusion of self nucleic acids from TLR-containing early endosomes normally prevents pDC responses to them

In some autoimmune diseases, self nucleic acids can be modified by host factors and gain entrance to pDC endosomes, where they activate TLR signaling

Several pDC receptors negatively regulate type I IFN responses by pDCs during viral infection and for normal homeostasis.

Notes:

Description based on publisher supplied metadata and other sources.

Animated audio-visual presentation with synchonized narration.

Title from title frames.

Publisher Number:

2077 Henry Stewart Talks