Modular protein-protein interactions provide a general mechanism to organize dynamic cellular systems / T. Pawson.

Format:

Video

Author/Creator:

Pawson, T., author.

Series:

Henry Stewart talks.

Henry Stewart talks

Language:

English

Subjects (All):

Phosphorylation.

Physical Description:

1 videorecording (51 min., 05 sec.) : sound, color.

Place of Publication:

London : Henry Stewart Talks, 2010.

System Details:

video file

Contents:

Printable Handouts

Navigable Slide Index

Introduction

Oncogenic transformation by v-Src

SH2 domains of cytoplasmic tyrosine kinases

Interaction between tyrosine kinase receptors

Signaling through regulated protein interactions

Interaction domains in cellular regulation

Features of interaction domains

Design of SH2 domain signaling proteins

SH2 binding sites on the beta-PDGF receptor

Specific SH2 phosphopeptide interaction

SH2 domain selectivity

SH2 domain specificity (1)

SH2 domain specificity (2)

WT and mutant SH2 domain structure

Recognition motifs in signal transduction

SH3 domains have a modular structure

SH3 domain versatility

Signaling from the T cell antigen receptor

The Gads SH2/SH3 adaptor links LAT to SLP-76

Mode of peptide recognition by Gad SH3-C

Interaction domains are adaptable

Mechanisms of interaction surfaces for signaling

Functions of interaction domains (1)

Physiological functions of interaction domains

Functions of interaction domains (2)

Interactions regulated by Ser/Thr phosphorylation

Phosphorylation and ubiquitin ligase complex (1)

Phosphorylation and ubiquitin ligase complex (2)

Cdc4 WD40 domain

Mechanism of Sic1 degradation

Activation of S-phase CDK

14-3-3 proteins bind sites as dimers

Regulation of protein function by 14-3-3 binding

Functional 14-3-3 binding

Physiological functions of interaction domains (1)

Adaptors couple receptors to intracellular targets

Signaling pathway through an adaptor protein

PTB domain proteins serve as scaffolds

Different receptors use signaling adaptors

Physiological functions of interaction domains (2)

Re-iterated use of interaction domains

Physiological functions of interaction domains (3)

Interaction domains control Src function

Interaction domains can be combined

The Abl SH3 domain

Rewiring cellular signaling by pathogenic proteins

Nck adaptors in cytoskeletal regulation

Enteropathogenic E.Coli (EPEC)

EPEC manipulates the cell cytoskeleton via Nck

Nck1 and Nck2 in pedestal formation

Oncogenic rewiring

Rewiring using chimaric adaptor proteins

Therapeutic possibilities of protein interactions

Conclusion.

Notes:

Description based on publisher supplied metadata and other sources.

Retrieved April 12, 2024, from https://hstalks.com/bs/1881/.