Innate immunity in children / Prof. David Speert - University of British Columbia, Canada.

Format:

Video

Author/Creator:

Speert, D. P. (David P.), author.

Language:

English

Subjects (All):

Natural immunity.

Immunity.

Physical Description:

1 videorecording (38 mins., 38 sec.) : sound, color

Place of Publication:

London, England : Henry Stewart Talks Ltd, 2009.

System Details:

video file

Contents:

Introduction

Outline

What is innate immunity? (1)

Critical role of innate immunity in children (1)

Critical role of innate immunity in children (2)

Elements of the immune system (1)

Elements of the immune system (2)

Defect in nonspecific immunity

Defect in adaptive immunity

Elements of the innate immune system

The cellular and humoral arms

Cellular elements for innate defense

Functions of the phagocytic system

Humoral arm of the innate immune system

Complement in innate defense

Complement cascade

Opsonization

Complement-mediated lysis

Inflammation: a fine balance

The canonical NFkappa-B pathway

Innate immunity

sensing and signaling

NF-kappa-B structure

Defects that cause immunodeficiency in children

Inflammatory dysfunction

Child with IRAK-4 deficiency

IRAK-4 deficient macrophage response to LPS

Phenotype of IRAK-4 deficiency

STAT-1 deficiency

UNC-93B deficiency

IL-12 / interferon-gamma axis defect

Phagocytes in innate defense

Phagocytosis

Leukocyte adhesion deficiency

Lesions in LAD patient

LAD patient at one year of age

Chronic granulomatous disease

Molecular defects in CGD

Manifestations of CGD

Patient with mild CGD

Patient with severe CGD

Genetic polymorphisms and the innate immunity

Therapeutic approaches

Strategies to enhance/arm innate immune system

Conclusions.

Notes:

Description based on: online resource; title from PDF information screen (Henry Stewart Talks Biomedical and Life Sciences Collection, viewed April 5, 2024).

Retrieved April 10, 2024, from https://hstalks.com/bs/1312/.