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Germline pharmacogenomics as a tool to individualize therapy in breast cancer / David A. Flockhart.
- Format:
- Video
- Author/Creator:
- Flockhart, David A., author.
- Language:
- English
- Subjects (All):
- Breast--Diseases.
- Breast.
- Physical Description:
- 1 online resource (1 streaming video file (42 min., 36 sec.)) : sound, color
- Place of Publication:
- London, England : Henry Stewart Talks, 2009.
- System Details:
- video file
- Contents:
- Introduction
- Major clinical issues in the personalized treatment
- The efficacy barrier: tamoxifen
- The efficacy barrier: tamoxifen and anastrozole
- Advances in targeting have improved the treatment
- Tumor based expression arrays
- Prognostic expression arrays
- The fisrt pharmacogenetic principle
- Principals for valuable predictive biomarkers
- The COBRA
- Anti-estrogen therapy for breast cancer
- Case report
- The ELPH trial
- Aromatase inhibitor side effects in the ELPh trial
- Drop out rates from aromatase inhibitors
- The problem with aromatase inhibitors in Asia
- Breast cancer around the world
- Oxford overview
- Classic understanding of tamoxifen pharmacology
- Tamoxifen metabolism
- Endoxifen and 4-OH-tamoxifen (1)
- Endoxifen and 4-OH-tamoxifen (2)
- Paroxetine and CYP2D6 genotype
- Predicting efficacy by serum concentrations
- CYP2D6 variant genotype and CYP2D6 inhibitors
- CYP2D6 inhibition and endoxifen concentrations
- Relapse free survival
- CYP2D6 inhibitor data inclusion
- Databank data
- Stratifying patients according to genotype
- Japanese women carrying the CYP2D6 *10 allele
- Unanswered questions
- Clinical consequences
- Pharmacodynamic pharmacogenomics
- Women with hot flashes do better
- Multiple targets to inhibit angiogenesis
- Bevacizumab in breast cancer
- PFS, ORR and OS
- No subgroup that could be determined to do well
- Financial consequences of FDA decisions
- VEGF -2578 AA and -1154 AA tagSNPs (1)
- VEGF -2578 AA and -1154 AA tagSNPs (2)
- VEGF genetic variability
- Summary
- Thank you.
- Notes:
- Description based on publisher supplied metadata and other sources.
- Retrieved April 11, 2024, from https://hstalks.com/bs/1124/.
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