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Protein homeostasis in mitochondria : AAA+ chaperones & proteases / David A. Dougan.
- Format:
- Video
- Author/Creator:
- Dougan, David A., (La Trobe University, Australia), Speaker.
- Series:
- Henry Stewart talks. Biomedical & life sciences collection. Protein homeostasis.
- Protein homeostasis : folding proteins and maintaining the protein-protein interaction networks, 2056-452X
- Language:
- English
- Subjects (All):
- Homeostasis.
- Mitochondria.
- Molecular chaperones.
- Proteins--Metabolism.
- Proteins.
- Mitochondria--metabolism.
- Mitochondrial Proteins--metabolism.
- Molecular Chaperones--metabolism.
- Medical Subjects:
- Mitochondria--metabolism.
- Mitochondrial Proteins--metabolism.
- Molecular Chaperones--metabolism.
- Physical Description:
- 1 videorecording (21 min., 58 sec.)
- Place of Publication:
- London : Henry Stewart Talks, 2012.
- System Details:
- video file
- Contents:
- Contents: Protein homeostasis in mitochondria
- Mitochondria play an important role in ageing and disease
- Quality control of mitochondria is controlled at three different levels
- Protein quality control (PQC) in mitochondria is maintained by mitochondrial chaperones and AAA+ proteases
- Following proteotoxic stress a specific mitochondrial unfolded protein response (mtUPR) is activated
- The AAA+ protease CLPXP is proposed to play a key role in mtUPR signaling
- A novel mtCLPX interacting protein that modulates the activity of mtCLPXP both in vitro and in vivo has been identified.
- Notes:
- Description based on publisher supplied metadata and other sources.
- Animated audio-visual presentation with synchronized narration.
- Title from title frames.
- Publisher Number:
- 3140 Henry Stewart Talks
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