Toll-Like receptor signaling and the innate immune response / Dr. Kate Fitzgerald.

Format:

Video

Author/Creator:

Fitzgerald, Dr. Kate, author.

Language:

English

Subjects (All):

Natural immunity.

Physical Description:

1 videorecording (30 min., 33 sec.)

Place of Publication:

London : Henry Stewart Talks Ltd, 2012.

System Details:

video file

Contents:

Introduction

Why we need innate immunity

Innate immune recognition of microbial products

Gram-negative lipopolysaccharides (1)

Gram-negative lipopolysaccharides (2)

How LPS is recognized

Cloning of Drosophila Toll

Leucine-rich repeats (LLR) in TLRs

The TLR/IL-1R superfamily

LPS hypo-responsive C3H/HeJ mice

Ligand induced activation of TLR3

Pattern recognition, MD-2

MD-2 has a "pocket" for LPS

The TLR4-MD-2-LPS complex

All infectious diseases involve TLRs

Localization of TLRs

Significance of endosomal localization of TLR9

Heterologous expression of TLR4

Generic model of signaling by all PRRs

LPS triggers activation of NFkB-driven cytokines

Studying pathway activation in MyD88-/- mice

MyD88 independent pathway

MyD88 dependent vs. independent pathways

TLRs signal through TIR domain adapter molecules

TLR signaling: schematic representation

LPS triggers two major signaling pathways

TLR4 and TLR3 signaling pathways

Adaptor molecule localization

LPS activation of TLR4: model (1)

Post translational modification of TRAM

TRAM mutant

LPS activation of TLR4: model (2)

Sorting vs. Signaling adapters

Delivery of TLR4 to phagosomes

Signaling downstream of TRIF/TRAM

Phosphorylation induced activation of IRF-3

IKK-related kinase TBK1

Control of TLR signaling by soluble TLRs

Transmembrane & intracellular regulators of TLR.

Notes:

Description based on publisher supplied metadata and other sources.

Retrieved April 13, 2024, from https://hstalks.com/bs/2314/.