Antibiotic resistance : a mechanistic overview / Dr. Neil Woodford.

Format:

Video

Author/Creator:

Woodford, Dr. Neil, author.

Language:

English

Subjects (All):

Drug Resistance, Microbial.

Physical Description:

1 videorecording (41 min., 45 sec.)

Other Title:

Antibiotic resistance

Place of Publication:

London : Henry Stewart Talks Ltd, 2009.

System Details:

video file

Contents:

Introduction

Mechanisms of antibiotic action

Resistance is as old as antibiotics

Antibiotic resistance mechanisms

Types of resistance

Defining resistance

Susceptibility is an interplay of multiple factors

Antibiotics select resistant bacteria

Bacteria carry resistance in their DNA

Resistance is transferred (1)

Resistance is transferred (2)

The Red Queen Principle

Resistance is inevitable

How quickly does resistance emerge?

Oxazolidinone timeline

Mechanism 1: alteration of the target

The forensics of antibiotic resistance

Epidemiological investigation of resistance

Surveillance of resistance

An example of a trend noticed in surveillance

Mechanism 2: metabolic by-pass

Cephalosporin-resistant E. coli

Why might resistance rates rise?

Understanding rising prevalence

Mechanism 3: drug destruction

Global explosion of CTX-M ESBLs

Multi-resistance plasmids

The use of carbapenems

Mechanism 4: reduced uptake

Restore porins and reverse carbapenem resistance

Carbapenemase-mediated resistance in the UK

The OXA-23 clone 1

Mechanism 5: up-regulated efflux

Recap: mechanisms of resistance

Undefined mechanism of action

Undefined resistance mechanisms

Summary

Acknowledgements.

Notes:

Description based on publisher supplied metadata and other sources.

Retrieved April 12, 2024, from https://hstalks.com/bs/1530/.