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Systemic RNA interference (RNAi) therapeutics for the treatment of HIV-1 / John Rossi.
- Format:
- Video
- Author/Creator:
- Rossi, John, (Beckman Research Institute of the City of Hope, USA), Speaker.
- Series:
- Henry Stewart talks. Biomedical & life sciences collection. Antivirals.
- Antivirals : latest developments and future progress, 2056-452X
- Language:
- English
- Subjects (All):
- Antiviral agents.
- Gene therapy.
- HIV infections--Treatment.
- HIV infections.
- Small interfering RNA--Therapeutic use.
- Small interfering RNA.
- Acquired Immunodeficiency Syndrome--drug therapy.
- Anti-HIV Agents--therapeutic use.
- Genetic Therapy.
- HIV Infections--drug therapy.
- HIV-1--drug effects.
- Molecular Targeted Therapy.
- RNA Interference.
- RNA, Small Interfering--therapeutic use.
- Medical Subjects:
- Acquired Immunodeficiency Syndrome--drug therapy.
- Anti-HIV Agents--therapeutic use.
- Genetic Therapy.
- HIV Infections--drug therapy.
- HIV-1--drug effects.
- Molecular Targeted Therapy.
- RNA Interference.
- RNA, Small Interfering--therapeutic use.
- Physical Description:
- 1 video recording (37 min., 47 sec.) : sound, color
- Place of Publication:
- London : Henry Stewart Talks, 2014.
- System Details:
- video file
- Contents:
- Contents: Systemic RNA interference (RNAi): Therapeutics for the treatment of HIV-1
- HIV life cycle
- Typical Course of HIV infection
- Why do we need new HIV drugs?
- Major goals of anti-HIV therapies
- Combinatorial RNA based therapy for HIV
- Applying RNAi for the treatment of human diseases
- treat HIV infection by systemic delivery of small RNAs
- Aptamers
- Chimeric-siRNA aptamer uptake into gp120 expressing cells
- Aptamer-targeted RNA interference for HIV-1 therapy
- Aptamer and aptamer chimera mediated inhibition of HIV-1
- Small animal model for studying anti-HIV RNAi based therapies
- Both aptamer and aptamer chimera inhibit HIV infection -Aptamer and chimeric aptamer-siRNA prevent CD4+ cell decline
- Aptamer and dsiRNAS effect on viral load
- Flexible PAMAM dendrimers with a triethanolamine core
- Dendrimers plus siRNAs form nanoparticles, protect siRNA from degradation and deliver siRNAs to T-lymphocytes
- G5 dendrimer delivered siRNAs down regulate target mRNAs in vitro
- Multiplex siRNAs for HIV-1 treatment
- In vivo analyses of G5 dendrimer delivered siRNAs
- Reductions in HIV loads following dendrimer siRNA injections
- Dendrimer-siRNA complexes protect HIV infected RAG-hu mice from CD4 T cell loss
- Bio distribution of G5 dendrimer siRNAs.
- Notes:
- Description based on: online resource; title from information screen (HSTalks, viewed April 12, 2024).
- Animated audio-visual presentation with synchronized narration.
- Title from title frames.
- Publisher Number:
- 3250 Henry Stewart Talks
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