Legionella pneumophila : an intracellular pathogen of phagocytes / Craig Roy.

Format:

Video

Author/Creator:

Roy, Craig, author.

Language:

English

Subjects (All):

Bacterial diseases.

Gram-negative bacterial infections.

Physical Description:

1 videorecording (43 min., 16 sec.)

Other Title:

Legionella pneumophila

Place of Publication:

London : Henry Stewart Talks Ltd, 2009.

System Details:

video file

Contents:

Introduction

Legionella pneumophila

The Legionella lifecycle

The dot and icm genes

dot/Icm define type 4 secretory system

Dot/Icm and intracellular replication

Endocytic membrane transport

Dot/Icm effect on endocytic maturation

Understanding the function of Dot/Icm

Dot/Icm and transport of Legionella vacuole

Legionella subverts vesicular transport

Legionella replication requires vesicular transport

ARF function is required for ER remodeling

ER-derived vesicles and Legionella vacuole

Host GTPases are used for replication

The Dot/Icm system modulates Arf

The Dot/Icm system modulates Rab1

Control of Arf and Rab GTPases

Identifying Legionella effector proteins

Identification of ralF

RalF is translocated to the bacterial cell

Dot/Icm delivers RalF to the host cell

RalF defines a new bacterial member of Sec7

Activation of Arf by Legionella

How does Legionella modulate Rab1 function?

Identification of DrrA

DrrA functions as a GEF factor

Other Legionella factors that target Rab1

DrrA is sufficient for Rab1 recruitment

DrrA is able to dissociate GDI from Rab1

DrrA has GDI displacement activity

DrrA has 2 functions

LepB interacts specifically with Rab1-GTP (1)

LepB interacts specifically with Rab1-GTP (2)

LepB is a Rab1 GAP

Control of Rab1 membrane cycling

Legionella: the greatest cell biologist on earth.

Notes:

Description based on: online resource; title from PDF information screen (Henry Stewart Talks Business & Management Collection, viewed April 12, 2024).

Retrieved April 12, 2024, from https://hstalks.com/bs/1465/.