1 option
Use of heparosan polysaccharide to enhance drug delivery / Paul L. DeAngelis.
Henry Stewart Biomedical & Life Sciences Collection Available online
Henry Stewart Biomedical & Life Sciences Collection- Format:
- Video
- Author/Creator:
- DeAngelis, Paul L., author.
- Language:
- English
- Subjects (All):
- Polymeric drug delivery systems.
- Physical Description:
- 1 videorecording (28 min., 27 sec.) : sound, color
- Place of Publication:
- London : Henry Stewart Talks, 2012.
- System Details:
- video file
- Contents:
- Introduction
- 'Sugar' roles & codes
- 'Sugar' therapeutics
- Drug needs and issues
- Market needs and issues (1)
- Market needs and issues (2)
- Background - Heparosan? (1)
- Background - Heparosan? (2)
- Technology
- Technology - stealth rationale
- Structure of Heparan Sulfate
- Advantages over PEG - bio-inert
- Advantages over PEG - bio-stealthy
- Advantages over PEG - bio-compatible
- Heparosan as a drug delivery vehicle
- Technology overview: PmHS1
- Technology overview - polymer production
- Synthesis of monodisperse Heparosan polymers
- Cargo-coupling chemistries include
- Technology - animal studies
- Technology - half-life study
- Technology - drug stability
- Technology - no accumulation in organs
- Technology - safe degradation
- Technology - cargo coupling
- Technology - cargo coupling via sulhydryls
- Technology - activity of HEP-G-CSF
- Technology - Heparosan toxicology (1)
- Technology - Heparosan toxicology (2)
- Technology - summary
- Value proposition
- Acknowledgements.
- Notes:
- Description based on publisher supplied metadata and other sources.
- Retrieved April 13, 2024, from https://hstalks.com/bs/2425/.
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