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Targeting Aß oligomers : a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease / William L. Klein.
- Format:
- Video
- Author/Creator:
- Klein, William L., (Northwestern University, USA), Speaker.
- Series:
- Henry Stewart talks. Biomedical & life sciences collection. Drug discovery and development in the neurosciences.
- Drug discovery and development in the neurosciences, 2056-452X
- Language:
- English
- Subjects (All):
- Alzheimer's disease--Chemotherapy.
- Alzheimer's disease.
- Alzheimer's disease--Diagnosis.
- Alzheimer's disease--Pathogenesis.
- Amyloid beta-protein.
- Nervous system--Degeneration.
- Nervous system.
- Alzheimer Disease--drug therapy.
- Alzheimer Disease--etiology.
- Alzheimer Disease--metabolism.
- Alzheimer Disease--pathology.
- Amyloid beta-Peptides--metabolism.
- Brain--metabolism.
- Neurodegenerative Diseases--metabolism.
- Neurons--metabolism.
- Neurons--pathology.
- Medical Subjects:
- Alzheimer Disease--drug therapy.
- Alzheimer Disease--etiology.
- Alzheimer Disease--metabolism.
- Alzheimer Disease--pathology.
- Amyloid beta-Peptides--metabolism.
- Brain--metabolism.
- Neurodegenerative Diseases--metabolism.
- Neurons--metabolism.
- Neurons--pathology.
- Physical Description:
- 1 videorecording (1 hr., 07 min., 43 sec.)
- Other Title:
- Amyloid beta oligomers : pathogenic ligands that attack dendritic spines
- Aß oligomers : pathogenic ligands that attack dendritic spines
- Targeting AB oligomers
- Targeting amyloid beta oligomers
- Place of Publication:
- London : Henry Stewart Talks, 2014.
- System Details:
- video file
- Contents:
- Contents: The oligomer cascade hypothesis for Alzheimer's Disease
- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis
- The role of AβOs in memory failure and the major facets of AD neuropathology
- Mechanisms by which AβOs instigate neurotoxicity
- Why AβOs accumulate in the first place
- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics
- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.
- Notes:
- Description based on: online resource; title from PDF information screen (Henry Stewart Talks Business & Management Collection, viewed April 5, 2024).
- Animated audio-visual presentation with synchronized narration.
- Title from title frames.
- Publisher Number:
- 3594 Henry Stewart Talks
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