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Pharmacogenetics of tardive dyskinesia. 2 : a "movement" towards individualized therapy / Vincenzo S. Basile.

Henry Stewart Biomedical & Life Sciences Collection Available online

Henry Stewart Biomedical & Life Sciences Collection
Format:
Author/Creator:
Language:
English
Subjects (All):
Physical Description:
1 streaming video file (50 min.) : digital, mono, SWF file, sound, color
Other Title:
Pharmacogenetics of tardive dyskinesia
Place of Publication:
London : Henry Stewart Talks Ltd, 2007.
System Details:
video file
Summary:
Audio-visual presentation : Pharmacokinetics and TD: a look at the cytochrome P450 system ; Oxidative stress and TD: a look at free radicals and the superoxide dismutase genes ; Psychiatric pharmacogenetics as cleaner complex phenotypes ; Neuroimaging in pharmacogenetics: towards even cleaner phenotypes ; Complex traits and new statistical models for looking at multigene interactions with continuous variables ; Recommendations for future studies: bringing pharmacogenetics from "Bench to Bedside" and from "Bedside back to Bench" ; Onward towards individualized pharmacotherapy.
Contents:
  • Introduction
  • Pharmacokinetic candidates: CYP1A2
  • CYP2D6: variation in drug metabolism
  • CYP2D6 gene: hypothesis of TD
  • Why CYP1A2? (1)
  • CYP1A2 vs. CYP2D6: multi-dose vs. single-dose
  • Why CYP1A2? (2)
  • Functional polymorphism in CYP1A2
  • CYP1A2 Bsp I polymorphism: mean AIMS scores
  • Stratified analysis
  • TD and CYP1A2 gene: references
  • TD and other CYP genes: references
  • TD and CYP2D6 gene: meta-analysis
  • Other candidate genes: DRD2, DRD4, CYP2D6
  • Oxidative stress candidates: MnSOD gene
  • Free radical: hypotheses of TD
  • Free radicals, glutamatergic system and TD
  • MnSOD gene: hypothesis of TD
  • Why MnSOD?
  • Functional polymorphism in MnSOD
  • MnSOD A9V polymorphism: mean AIMS scores
  • TD and MnSOD gene: references
  • Gene-gene interactions
  • Models for specific gene-gene interactions (1)
  • Models for specific gene-gene interactions (2)
  • DRD3 Msc I polymorphism: mean AIMS scores
  • DRD3 and CYP1A2 interactions
  • DRD3 and MnSOD interactions
  • DRD3 and BDNF interactions
  • DRD3 and 17-alpha-hydroxylase interactions
  • DRD3 and HTR2C interactions
  • Summary
  • Genetic association strategy: limitations
  • Possibilities for the future
  • Recommendations for future studies
  • Full models of prediction, artificial neural networks
  • How do we find these genes?
  • Contact information.
Notes:
  • Description based on publisher supplied metadata and other sources.
  • Retrieved April 7, 2024, from https://hstalks.com/bs/272/.

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