Pathogenic mechanisms in prion disease / Giovanna Mallucci.

Format:

Video

Author/Creator:

Mallucci, Giovanna (University College London, UK), Speaker.

Series:

Henry Stewart talks. Biomedical & life sciences collection. Genetic basis of neurological disorders.

The genetic basis of neurological disorders, 2056-452X

Language:

English

Subjects (All):

Nervous system--Degeneration.

Nervous system.

Nervous system--Diseases--Genetic aspects.

Prion diseases.

Protein folding.

Proteins--Metabolism--Disorders.

Proteins.

Neurodegenerative Diseases.

Prion Diseases.

Protein Folding.

Proteostasis Deficiencies.

Unfolded Protein Response.

Medical Subjects:

Neurodegenerative Diseases.

Prion Diseases.

Protein Folding.

Proteostasis Deficiencies.

Unfolded Protein Response.

Physical Description:

1 videorecording (32 min., 14 sec.) : sound, color.

Place of Publication:

London : Henry Stewart Talks, 2014.

System Details:

video file

Contents:

Contents: Neurodegenerative diseases and protein misfolding disorders

Prion disease in mice to study mechanisms of neurodegeneration due to misfolded protein accumulation

Early prion neurodegenerative change is reversible: access to key neurotoxic pathways

Critical change is loss of synaptic proteins due to activation of PERK branch of the unfolded protein response

Modifying this pathway genetically is neuroprotective

Modifying this pathway pharmacologically is neuroprotective

Relevance of this pathway in other neurodegenerative diseases with misolded proteins e.g. Alzheimer's and Parkinson's and ALS

Relevance in learning and memory

Common target for therapy in these disorders.

Notes:

Animated audio-visual presentation with synchronized narration.

Title from title frames.

Publisher Number:

3786 Henry Stewart Talks