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Segregation analysis / C. Cannings, Dawn Teare.
- Format:
- Video
- Author/Creator:
- Cannings, C., author.
- Teare, Dawn, author.
- Language:
- English
- Subjects (All):
- Disease susceptibility.
- Physical Description:
- 1 streaming video file (38 min.) : digital, mono, SWF file, sound, color
- Place of Publication:
- London : Henry Stewart Talks Ltd, 2004.
- System Details:
- video file
- Summary:
- Audio-visual presentation : Components of segregation analysis ; Maximum likelihood models ; Peeling and MCMC ; Estimating the segregation proportion ; Ascertainment/sampling bias ; Ascertainment correction ; Segregation analysis for quantitative traits ; Polygenic models ; Heritability ; Components of variance ; Genetic variance: additive and dominance ; Epistatic variance ; Analysis of covariance ; Mixed models ; Liability and threshold models ; The hypergeometric polygenic model ; Regressive models ; Penetrance functions ; Survival models ; Computer packages.
- Contents:
- Introduction
- Segregation analysis: fitting a genetic model
- Parts of segregation analysis
- Maximum likelihood
- Likelihood
- Peeling
- MCMC
- Example
- Classic segregation analysis
- Estimating the segregation proportion
- Ascertainment / sampling bias
- Ascertainment probability
- Special cases
- Selected through affected
- Ascertainment correction
- Ascertainment criteria
- Ascertainment problems
- Segregation analysis for quantitative traits
- Quantitative traits
- QTL
- Polygenic model
- Polygenic values
- Polygenes responsible for a quantitative trait
- Polygenic inheritance
- Heritability
- Components of variance
- Heritability (1)
- Heritability (2)
- Heritability (3)
- Heritability (4)
- Heritability (5)
- Additive genetic variance
- Dominance variance
- Epistatic variance
- Total variance
- Covariance between pairs of relatives (1)
- Covariance between pairs of relatives (2)
- Covariance between pairs of relatives (3)
- Analysis of covariance
- Segregation analysis and the mixed model (1)
- Segregation analysis and the mixed model (2)
- Segregation analysis and the mixed model (3)
- Likelihood for the mixed model
- Liability and threshold models
- Liability thresholds
- Polygenic approximations
- The hypergeometric polygenic model
- Hypergeometric approximation (1)
- Hypergeometric approximation (2)
- Regressive models
- Penetrance functions
- Survival models
- Hazard rate (1)
- Hazard rate (2)
- Survival
- Estimation (1)
- Estimation (2)
- Summary
- Complex segregation analysis (1)
- Complex segregation analysis (2)
- Common problems in segregation analysis
- Global or local maximum likelihood?
- Computer packages
- Graphical models and MCMC
- Segregation analysis: the future (1)
- Segregation analysis: the future (2)
- Segregation analysis: the future (3).
- Notes:
- Description based on publisher supplied metadata and other sources.
- Retrieved April 9, 2024, from https://hstalks.com/bs/23/.
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