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Statistical characterization of genetic association / by Prof. Bruce Weir.
- Format:
- Video
- Author/Creator:
- Weir, B. S. (Bruce S.), 1943- author.
- Language:
- English
- Subjects (All):
- Medical genetics--Research--Methodology.
- Medical genetics.
- Genetics--Statistical methods.
- Genetics.
- Physical Description:
- 1 videorecording (57 min., 25 sec.) : sound, color
- Place of Publication:
- London : Henry Stewart Talks Ltd, 2004.
- System Details:
- video file
- Summary:
- Audio-visual presentation : Alternative methods of estimating and testing hypotheses ; Causes and description of departures from independence of alleles at one, two or three loci ; Effects of multiple alleles ; Comparison of allelic and genotypic association tests in the case-control setting ; Trend tests.
- Contents:
- Introduction
- Genetic association
- Genotype notation
- Allele notation
- One-locus association
- Inbreeding coefficient
- Multiple alleles
- Hardy-Weinberg testing
- Power of HW test
- Two-locus association
- Linkage disequilibrium testing
- HW, LD statistics comparison
- Variance of HW, LD statistics
- Estimating gamete frequencies
- EM algorithm
- Composite disequilibrium
- Composite LD estimate
- General disease model
- Disease associations
- Detecting association with HWD
- Case-control comparison
- Case-control test
- Contingency-table tests
- Populations not in HWE
- Haplotype associations
- Haplotype association parameter
- Four-locus association
- Four-locus LD
- Three-locus LD test
- Three-locus test partition
- Two-locus normal-based test
- Three-locus normal-based test
- Two-locus LD bounds
- Two-locus bounds example
- Three-locus bounds
- Four-locus bounds
- References
- Acknowledgements.
- Notes:
- Description based on publisher supplied metadata and other sources.
- Retrieved April 9, 2024, from https://hstalks.com/bs/36/.
- Includes bibliographical references.
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