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Quantitative analysis of receptor allosterism and its implication for drug discovery / Rumin Zhang.
- Format:
- Video
- Author/Creator:
- Zhang, Rumin, (Merck, USA), Speaker.
- Series:
- Henry Stewart talks. Biomedical & life sciences collection.
- The biomedical & life sciences collection, 2056-452X
- Language:
- English
- Subjects (All):
- Cell receptors.
- Drug development.
- Drug receptors.
- Pharmaceutical chemistry.
- Drug Agonism.
- Drug Discovery.
- Receptors, Cytoplasmic and Nuclear.
- Receptors, G-Protein-Coupled--agonists.
- Receptors, G-Protein-Coupled--chemistry.
- Medical Subjects:
- Drug Agonism.
- Drug Discovery.
- Receptors, Cytoplasmic and Nuclear.
- Receptors, G-Protein-Coupled--agonists.
- Receptors, G-Protein-Coupled--chemistry.
- Physical Description:
- 1 videorecording (56 min., 32 sec.) : sound, color
- Place of Publication:
- London : Henry Stewart Talks, 2015.
- System Details:
- video file
- Contents:
- Contents: G protein-coupled receptors (GPCRs)
- Receptor agonism and allosterism
- Orthosteric and allosteric binders
- Inverse, partial and full agonists
- Positive, silent and negative allosteric modulators (PAMs, SAMs and NAMs)
- Allosteric two-state model and general operational model with constitutive receptor activity
- Optimal design of experiment
- Global curve fitting analysis of affinity and efficacy parameters
- Beta supremacy
- Monte Carlo simulations.
- Notes:
- Description based on publisher supplied metadata and other sources.
- Animated audio-visual presentation with synchronized narration.
- Title from title frames.
- Publisher Number:
- 4030 Henry Stewart Talks
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