ApoE4 - the most prevalent genetic risk factor for Alzheimer's disease / Daniel Michaelson.

Format:

Video

Author/Creator:

Michaelson, Daniel, author.

Language:

English

Subjects (All):

Apolipoproteins.

Physical Description:

1 streaming video file (53 min.) : color, sound

Place of Publication:

London : Henry Stewart Talks Ltd, 2012.

System Details:

video file

Contents:

Introduction

Alzheimer's disease (1)

Alzheimer's disease (2)

Outline of talk

Apolipoprotein E (ApoE)

ApoE genotype frequency in the population

ApoE4 decreases the age of onset of AD

ApoE4 dependent brain pathology in AD (1)

Isoform effects of ApoE4 on amyloid deposition

ApoE4 dependent brain pathology in AD (2)

Brain inflammation in ApoE4 positive patients

ApoE4 dependent brain pathology in AD (3)

ApoE4 role in neuronal remodeling & brain trauma

ApoE4 dependent brain pathology in AD (4)

ApoE4 & amyloid deposition on blood vessels

ApoE4 dependent brain pathology in AD (5)

The effects of ApoE4 start early

ApoE4 is a risk factor for other diseases

Age related macular degeneration and ApoE4

Pathological effects of ApoE4 - mechanisms

Phenotypic effects of ApoE4 in transgenic mice

Molecular mechanisms: lipid metabolism

ApoE and brain cholesterol

ApoE4 lipid cross talk: experimental design

Effects of ApoE4 diets & environmental stimulation

Effects of DHA and cholesterol on behavior

ApoE4 mechanisms (1)

Molecular mechanisms: amyloid cascade

Effects of human ApoE4 isoforms on brain A-beta

ApoE4 mechanisms (2)

In vivo activation of the amyloid cascade

ApoE4 driven accumulation of intracellular A-beta

Neuronal loss following accumulation of A-beta

Intracellular pathology and A-beta in ApoE4 mice

A-beta oligomerization (1)

A-beta oligomerization (2)

ApoE4-induced A-beta mediated neurotoxicity

ApoE4 mechanisms (3)

How do ApoE and A-beta interact

Molecular mechanisms: ApoE receptors

LDL receptor family members

ApoER2 and NMDA receptors

ApoER2 and NMDA receptors: ApoE4 toxicity

ApoE4 driven accumulation of A-beta by LRP

ApoE4 mechanisms (4)

Molecular mechanisms: ApoE4 catabolism

Conformation and catabolism of ApoE3 and ApoE4

Consequence of ApoE4 fragmentation

ApoE4 mechanisms (5)

Neurodegeneration, Vascular pathology

ApoE4 directed therapy

ApoE4: loss of function vs. gain of toxic function

A-beta accumulation by ApoE4: gain of function

ApoE4 related therapeutic approaches

ApoE4 affects the efficacy of clinical trials

Summary of talk

Acknowledgements.

Notes:

Description based on publisher supplied metadata and other sources.

Retrieved April 13, 2024, from https://hstalks.com/bs/2402/.