Regulation of the immune response to pathogens. Part 2 of 2 / Prof. Anne O'Garra - National Institute for Medical Research, London, UK.

Format:

Video

Author/Creator:

O'Garra, Anne, author.

Language:

English

Subjects (All):

Immune response--Regulation.

Immune response.

Host-parasite relationships--Immunological aspects.

Host-parasite relationships.

Physical Description:

1 videorecording (33 mins., 13 sec.) : sound, color

Place of Publication:

London, England : Henry Stewart Talks Ltd, 2012.

System Details:

video file

Contents:

Introduction

Talk outline

The immune response in tuberculosis

Protective factors in the immune response to Mtb

Protection or pathogenesis: T cells in TB

Protection or pathogenesis: cytokines in TB

Protection or pathogenesis: resistant/susceptible

Mtb: resistant & susceptible mouse models

Factors that regulate host responses in TB

Potential regulatory roles for IL-10 in Mtb

Suggestive roles for IL-10 in human TB

IL-10 in mouse models of TB: conflicting reports

Enhanced IL-10 production in "susceptible" mice

Experimental overview

IL-10 is produced in the lung during Mtb infection

Mtb in the absence of IL-10 in BALB/c mice

Mtb H37Rv infection in the absence of IL-10

Enhanced protection to Mtb: IL-10 & Th1 response

IL-10 in immune regulation during Mtb infection

The human immune response in tuberculosis

Tuberculosis: a major human threat (epidemiology)

Difficulties in dealing with tuberculosis

Tuberculosis: a major human threat (Dx and Tx)

2 billion people have "latent tuberculosis"

"Latent TB" into active TB: no test

Transcriptional signatures (latent vs. active TB)

Study design

Blood reflects cell migration throughout body

London the tuberculosis capital of Europe

Active vs. latent TB: distinct transcriptional profile

393 transcripts derived from statistical filtering

Blood transcriptional signature validation (London)

TB is a global disease

Outliers in Latent and Active Tuberculosis

Transcriptional signature in active TB (London)

Active TB signature correlates with radiography

Active TB signature is diminished on treatment

TB signatures for treatment monitoring

Transcriptional modules

Finding common clusters across diseases

Classical versus modular approach

Modular signature of active TB: UK vs. SA (1)

TB signature distinct from other diseases

Modular signature of active TB: UK vs. SA (2)

IFN-inducible genes present in active TB patients

Bacterial pathogens can induce IFN production

Type 1 IFN can down-regulate IFN-gamma receptor

Mtb infection and type 1 IFN

Human disease and experimental models

Acknowledgements

Collaborators

The MRC National Institute for Medical Research

The Francis Crick institute.

Notes:

Description based on: online resource; title from PDF information screen (Henry Stewart Talks Biomedical and Life Sciences Collection, viewed April 15, 2024).

Retrieved April 15, 2024, from https://hstalks.com/bs/2458/.