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Cytokines regulating the innate response / Prof. Anne O'Garra - National Institute for Medical Research, London, UK.
- Format:
- Video
- Author/Creator:
- O'Garra, Anne, author.
- Language:
- English
- Subjects (All):
- Cytokines.
- Natural immunity.
- Physical Description:
- 1 videorecording (54 mins., 07 sec.) : sound, color
- Place of Publication:
- London, England : Henry Stewart Talks Ltd, 2009.
- System Details:
- video file
- Contents:
- Introduction
- Adaptive immune response
- Th1 and Th2 cells in immune regulation
- Testing Th1 and Th2 differentiation
- IL-4 and IL-12 for the development of T cells
- Th1/ 2 existence in humans originally doubted
- Exemplifying the controversy
- Cytokines regulate the development of Th1/2 cells
- Th1/2 paths of differentiation and commitment
- Th2 pathway
- IL-12 and Th1 are required for resistance to MTb
- Role of TNF in controlling MTb infection in humans
- Regulation of IFN-gamma production by Th1 cells
- The IL-12 family
- IL-12 versus IL-23 in antimicrobial responses
- IL-12 and IFN-gamma in infection and pathology
- IL-23 is the critical cytokine for EAE pathology (1)
- Immunized cells expressing different cytokines
- IL-23 is the critical cytokine for EAE pathology (2)
- Th1 and ThIL-17
- Confirmation of IL-23 and IL-12 roles in immunity
- TGF-beta
- Summary of CD4 T cells differentiation pathways
- TGF-beta requirement for TH-17 development (1)
- TGF-beta requirement for TH-17 development (2)
- The different T cell subsets
- Importance of regulating inflammatory responses
- IL-10 production and function
- Foxp3 regulatory T cells
- The discovery of IL-10
- B cells produce IL-10 and can stimulate Th1 cells
- IL-10: an anti-inflammatory cytokine
- IL-10 limits the immune response
- Role of IL-10 in immune responses
- Differentiation of IL-10 producing T cells
- In vivo peptide antigen tolerization protocol
- Results from the repeated administration of antigen
- Tolerance induction by soluble antigen
- TCR- transgenic transfer model for tolerance
- Effect of IL-10 neutralization and LPS presence
- IL-10 knockout versus Foxp3 knockouts
- IL-10 production - summary
- Complexity of the immune response
- Innate immune response
- TLR dependent and independent induction of IL-10
- Cytokines limit immunopathology
- IL-10 suppresses the immune response to MTb
- Summary
- Outstanding questions
- Future thinking.
- Notes:
- Description based on: online resource; title from PDF information screen (Henry Stewart Talks Biomedical and Life Sciences Collection, viewed April 5, 2024).
- Retrieved April 10, 2024, from https://hstalks.com/bs/1300/.
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