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HIV-1 and immunopathogenesis : innate immunity / Luis J. Montaner.
Henry Stewart Biomedical & Life Sciences Collection Available online
Henry Stewart Biomedical & Life Sciences Collection- Format:
- Video
- Author/Creator:
- Montaner, Luis J., author.
- Language:
- English
- Subjects (All):
- HIV infections--Prevention.
- HIV infections.
- Physical Description:
- 1 online resource (1 streaming video file (55 min., 41 sec.)) : sound, color
- Other Title:
- HIV-1 and immunopathogenesis
- Place of Publication:
- London, England : Henry Stewart Talks, 2009.
- System Details:
- video file
- Contents:
- Introduction
- Lecture acknowledgements
- Lecture outline
- Section 1 outline
- Global review: viral life cycle
- Viral transmission
- Global review: acute infection
- Global review: acute infection (2)
- Mechanism of viral entry
- Systemic spread of the virus post entry
- CD4+ depletion in the gut
- How does GALT depletion affect disease outcome
- Why does the viral load drop?
- The host immune response
- Viral "set point" as a predictor of disease
- Course of disease
- Innate and adaptive immune responses cross talk
- Monocytes and macrophages compartments
- Monocytes and macrophages: virus reservoirs
- Macrophages and HIV-1 infection
- HIV-1 and monocyte apoptosis
- Human DC subsets
- Model of DC migration and maturation
- MHC I antigen presentation
- Antigen presentation on MHC class I and II
- Proposed pathways of human DC development
- Characteristics of human DC
- DC role during HIV-1 infection
- Dendritic cell subsets
- DC decrease upon HIV infection
- Human DC: C-type lectins
- Types of C-type lectins expressed on DC
- Pathogens that bind DC-SIGN
- Natural killer (NK) cells
- Direct cytotoxicity through CD8+ T cells
- Natural killer cell recognition of target cells (1)
- Natural killer cell recognition of target cells (2)
- MHC class I locus and NK cells regulation
- The role of NK cell throughout the disease
- Role of HLA and KIR alleles in progression to AIDS
- NK cell and HIV-1 infection
- To kill or not to kill?
- Measuring the recovery of patients
- ART & innate reconstitution
- RO1 AI51225 - prospective study
- Recovery of PDC function with HIV-1 suppression
- Reconstitution of PDC and NK cytotoxicity
- Model of immune reconstitution time line
- Section 1 conclusions
- Section 2 outline
- Recent paradigm shift: viral load and CD4 loss
- Immune activation and disease progression
- Natural SIV host
- Natural host vs. the HIV model
- TLR7 and TLR9 signaling and immune activation
- HIV-1 Nef and immune activation
- LPS levels are increased in chronic HIV infection
- Human Toll-like Receptors (TLRs)
- HIV RNAs can activate T cells via TLR 7, 8
- TLR activation and CD4 T cells apoptosis
- TLR induce human T cell activation and death
- Immune activation hypothesis
- Disease model
- Summary model
- Major hypothesis
- Thank you.
- Notes:
- Description based on: online resource; title from PDF information screen (Henry Stewart Talks Biomedical and Life Sciences Collection, viewed April 12 2024).
- Retrieved April 12, 2024, from https://hstalks.com/bs/1307/.
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