HIV-1 and immunopathogenesis : innate immunity / Luis J. Montaner.

Format:

• Video

Author/Creator:

• Montaner, Luis J., author.

Language:

English

Subjects (All):

• HIV infections--Prevention.

Physical Description:

1 online resource (1 streaming video file (55 min., 41 sec.)) : sound, color

Other Title:

HIV-1 and immunopathogenesis

Place of Publication:

London, England : Henry Stewart Talks, 2009.

System Details:

video file

Contents:

• Introduction
• Lecture acknowledgements
• Lecture outline
• Section 1 outline
• Global review: viral life cycle
• Viral transmission
• Global review: acute infection
• Global review: acute infection (2)
• Mechanism of viral entry
• Systemic spread of the virus post entry
• CD4+ depletion in the gut
• How does GALT depletion affect disease outcome
• Why does the viral load drop?
• The host immune response
• Viral "set point" as a predictor of disease
• Course of disease
• Innate and adaptive immune responses cross talk
• Monocytes and macrophages compartments
• Monocytes and macrophages: virus reservoirs
• Macrophages and HIV-1 infection
• HIV-1 and monocyte apoptosis
• Human DC subsets
• Model of DC migration and maturation
• MHC I antigen presentation
• Antigen presentation on MHC class I and II
• Proposed pathways of human DC development
• Characteristics of human DC
• DC role during HIV-1 infection
• Dendritic cell subsets
• DC decrease upon HIV infection
• Human DC: C-type lectins
• Types of C-type lectins expressed on DC
• Pathogens that bind DC-SIGN
• Natural killer (NK) cells
• Direct cytotoxicity through CD8+ T cells
• Natural killer cell recognition of target cells (1)
• Natural killer cell recognition of target cells (2)
• MHC class I locus and NK cells regulation
• The role of NK cell throughout the disease
• Role of HLA and KIR alleles in progression to AIDS
• NK cell and HIV-1 infection
• To kill or not to kill?
• Measuring the recovery of patients
• ART & innate reconstitution
• RO1 AI51225 - prospective study
• Recovery of PDC function with HIV-1 suppression
• Reconstitution of PDC and NK cytotoxicity
• Model of immune reconstitution time line
• Section 1 conclusions
• Section 2 outline
• Recent paradigm shift: viral load and CD4 loss
• Immune activation and disease progression
• Natural SIV host
• Natural host vs. the HIV model
• TLR7 and TLR9 signaling and immune activation
• HIV-1 Nef and immune activation
• LPS levels are increased in chronic HIV infection
• Human Toll-like Receptors (TLRs)
• HIV RNAs can activate T cells via TLR 7, 8
• TLR activation and CD4 T cells apoptosis
• TLR induce human T cell activation and death
• Immune activation hypothesis
• Disease model
• Summary model
• Major hypothesis
• Thank you.

Notes:

• Description based on: online resource; title from PDF information screen (Henry Stewart Talks Biomedical and Life Sciences Collection, viewed April 12 2024).
• Retrieved April 12, 2024, from https://hstalks.com/bs/1307/.