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Fate of monocytes in atherosclerosis / Gwendolyn Randolph.

Henry Stewart Biomedical & Life Sciences Collection Available online

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Format:
Video
Author/Creator:
Randolph, Gwendolyn, author.
Language:
English
Subjects (All):
Natural immunity.
Physical Description:
1 online resource (1 streaming video file (53 min., 40 sec.)) : sound, color
Place of Publication:
London, England : Henry Stewart Talks, 2009.
System Details:
video file
Contents:
Introduction
Atherosclerosis
Areas of atherosclerotic plaques development
Accumulation of "dendritic cells" in the artery
TLR2 expression in endothelial cells
Early stage of the disease
Heterogeneity of macrophages in the plaques
DCs in human atherosclerotic plaques
Importance of monocytes in atherosclerosis
Hematopoietic cells involved in atherosclerosis
Human monocyte subsets
Differences between human monocyte subsets
Human vs. mouse monocyte subsets
A method for monitoring monocyte migration
Monocyte recruitment to plaques
Mouse monocyte recruitment to inflammatory sites
Inflammatory monocytes
Ly-6Clo monocytes role in plaques
Mannose receptor positive monocytes in plaques
Is the CX3CR1 allele athero-protective?
CX3CR1 as a survival factor
Progression of atherosclerosis
Features of advanced disease
Dramatic view of a necrotic core
Resolution of acute inflammation
Does this resolution occur in atherosclerosis?
Schematic diagram of atherosclerotic plaque
Leukocyte trafficking
Cells emigrate from lesions
CD68+ cell in the SMC medial layer of the artery
Migration of mononuclear phagocytes - method 1
DC-like cells fail to leave progressing plaques
Quantification of the surgical process
The effect of the surgical process
Migration of mononuclear phagocytes - method 2
Distinguishing death from trafficking
A schematic view of the monitoring process
Pulse-chase experiment
Late-time point of monitoring
Potential therapeutic targets
How is mobilization achieved?
Thank you.
Notes:
Description based on: online resource; title from PDF information screen (Henry Stewart Talks Biomedical and Life Sciences Collection, viewed April 12 2024).
Retrieved April 12, 2024, from https://hstalks.com/bs/1318/.

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