Recombination and the formation of chiasmata in meiosis / Matthew C. Whitby.

Format:

Video

Author/Creator:

Whitby, Matthew C., author.

Language:

English

Subjects (All):

Cell cycle.

Physical Description:

1 online resource (1 streaming video file (58 min., 19 sec.)) : sound, color

Place of Publication:

London, England : Henry Stewart Talks, 2009.

System Details:

video file

Contents:

Introduction

The Metazoan life cycle

Meiosis versus Mitosis

Mitotic chromosome segregation

Differences between mitosis and meiosis

Overview of talk

Homologous recombination

Meiotic prophase I

DSB repair model (Szostak et al., 1983)

Detection of meiotic recombination intermediates

Detection of SEIs and dHJs

Non-crossovers are probably formed by SDSA

sHJs give rise to crossovers in S. pombe

Chiasmata link the homologues by cohesin

Programmed DSBs during meiosis

DSB formation does not only depend on Spo11

DSB formation restricted to leptotene, prophase I

DSB can be uncoupled from DNA replication

Mer2 is phosphorylated at multiple sites

Mer2 phosphorylation is essential

Mer2 phosphorylation and DNA replication

Processing the DSB (1)

Structure of the MRX/N complex

Processing the DSB (2)

Pairing of homologous DNAs and strand invasion

How do Rad51 and Dmc1 function together?

Other factors needed for homologous pairing

Assembly of the Rad51/Dmc1 filament

Simple model for the aid of accessory proteins

Resolving HJ and crossover formation

The ZMM proteins and Class I crossovers

Mer3 and Msh4-Msh5

The synaptonemal complex

The nucleation of Zip1 polymerization

Class I crossovers need specific resolution of dHJ

Class II crossovers depend on Mus81-Eme1/Mms4

Conclusion

Reference.

Notes:

Description based on: online resource; title from PDF information screen (Henry Stewart Talks Biomedical and Life Sciences Collection, viewed April 12 2024).

Retrieved April 12, 2024, from https://hstalks.com/bs/1274/.