Invasion, metastasis and stem cells / Robert A. Weinberg.

Format:

Video

Author/Creator:

Weinberg, Robert A., author.

Series:

Henry Stewart talks.

Henry Stewart talks

Language:

English

Subjects (All):

Tumors.

Physical Description:

1 videorecording (38 min., 29 sec.) : sound, color.

Place of Publication:

London : Henry Stewart Talks, 2009.

System Details:

video file

Contents:

Printable Handouts

Navigable Slide Index

Introduction

Vogelstein-Kinzler model of cancer progression

Propagate epithelial cells in distinct culture media

The importance of normal cell of origin (CO)

CO determine tumor morphology and progression

Normal and cancer cells hierarchical organization

BPLER more competent to spawn metastases

The invasion metastasis cascade (IMC)

Two phases of the IMC

The last step of the IMC

The behavior of a BPLER xenograft in mouse host

EMT in BPLER mammary epithelial cells

Importance of cancer cells microenvironment

EMT is a complex process

EMT and embryogenesis

EMT in the primitive neural crest

Twist transcription factor

Transcription factors involved in EMT

Cancer cells use EMT for invasion

Twist acts pleiotropically to reprogram expression

Twist is essential for lung metastases

The effect of Twist on different steps of the IMC

Twist effects most of the IMC steps

Behavior of implanted transformed melanocytes

The Slug TF plays a prominent role in emigration

Slug enables emigration from primitive neural crest

Slug suppression strongly inhibits metastasis

The importance of FOXC2

FOXC2 expression in human breast cancer

FOXC2 associated with basaloid breast cancer (1)

FOXC2 associated with basaloid breast cancer (2)

The EMT-inducing TF intercommunicate (1)

The EMT-inducing TF intercommunicate (2)

What is the nature of cells generated by an EMT?

FOXC2 expression in normal and EMT cells

EMT product might be stem cells

Markers for carcinomal MESC

The effects of EMT induction on MEC (1)

Induction of EMT by Snail and Twist

Gene expression of MESC and ME non-SC

Stem-like cells express mesenchymal markers

Stem-like cells in primary human breast samples

Activation of Twist-ER or Snail-ER by tamoxifen

EMT and cancer progression

Most chemotherapies kill the non-CSCs.

Notes:

Description based on publisher supplied metadata and other sources.

Retrieved April 11, 2024, from https://hstalks.com/bs/1376/.