Chemokines and inflammation : a critical assessment of therapeutic targets / David R. Greaves.

Format:

Video

Author/Creator:

Greaves, David R., author.

Series:

Henry Stewart talks.

Henry Stewart talks

Language:

English

Subjects (All):

Natural immunity.

Physical Description:

1 videorecording (50 min., 49 sec.) : sound, color.

Other Title:

Chemokines and inflammation

Place of Publication:

London : Henry Stewart Talks, 2009.

System Details:

video file

Contents:

Printable Handouts

Navigable Slide Index

Introduction

About the author

Chemotaxis

Chemokines and inflammation

Talk outline

Introduction to chemokine biology (1)

Introduction to chemokine biology (2)

The chemokine family

The structural motifs of the chemokine subfamilies

Introduction to chemokine biology - GAGs (1)

Introduction to chemokine biology - GAGs (2)

Chemokine receptors (1)

Chemokine receptors (2)

Chemokine receptors and their ligands

Decoy chemokine receptors (1)

Decoy chemokine receptors (2)

Chemokine evolution (1)

Chemokine evolution (2)

Phylogeny of the chemokine system

Homology of chemokine receptors

Development of chemotaxis systems

Use of chemotaxis systems

The role of chemokines in inflammation

What is inflammation?

Acute inflammation

Chronic inflammation

CXC family of chemokines and acute inflammation

CXC signaling in acute inflammation

CC chemokines and chronic inflammation

Chronic inflammatory diseases

Chemokines and leukocyte recruitment

Homeostatic chemokines

Chemokine function in atherosclerosis

Atherosclerosis plaque formation

Atherosclerosis plaque formation and chemokines

Evidence to chemokine function in atherosclerosis

Regulation of chemokines after endothelial damage

The role of chemokines after endothelial damage

The work of Saederup et al.

The role of chemokines in plaque formation

The role of chemokines in plaque progression (1)

The role of chemokines in plaque progression (2)

The role of T cells in plaque formation

The work of Mach et al. (1)

The work of Mach et al. (2)

The work of Mach et al. (3)

Chemokine ligand-receptor pairs in atherosclerosis

CCL2 acting via CCR2

Machrophage staining

Decreased lesion size in CCR2 -/- mice

Atherogenesis in LDL-R MCP-1 double knockout

Multiple roles for CCL2 in atherogenesis

CCL2 as a direct target for statin therapy

CCL3,4,5 acting via CCR1 and CCR5

CCL5 and CCR1

The role of CCR1 and CCR5 in atherosclerosis

CXCL9,10,11 acting via CXCR3

CXCL10 apoE double KO mice (1)

CXCL10 apoE double KO mice (2)

CX3CL1 acting via CX3CR2

CX3CL1 apoE double KO (1)

CX3CL1 apoE double KO (2)

CX3CL1 apoE double KO (3)

CX3CR1 polymorphisms and cardiovascular risk

Targeting chemokines in atherosclerosis

Strategies for targeting chemokines

Neutralizing antibodies

Anti-CCR2 monoclonal antibody - clinical trial

Small molecule inhibitors

Small molecule inhibitors - TAK-779 (1)

Small molecule inhibitors - TAK-779 (2)

Small molecule inhibitors - NBI-74330 (1)

Small molecule inhibitors - NBI-74330 (2)

Mutant chemokines

N terminal chemokine mutants

Met- RANTES

N terminal mutant of CCL2

Chemokine oligomerization mutants (1)

Chemokine oligomerization mutants (2)

Broad spectrum chemokine blockade

Expression of 35kDa chemokine binding protein (1)

Expression of 35kDa chemokine binding protein (2)

Long term CC chemokine inhibition (1)

Long term CC chemokine inhibition (2)

Conclusions and future prospects (1)

Conclusions and future prospects (2)

Conclusions and future prospects (3)

Conclusions and future prospects (4)

Thank you.

Notes:

Description based on publisher supplied metadata and other sources.

Retrieved April 11, 2024, from https://hstalks.com/bs/1285/.